Cancer Antigen (CA) 125
Medical Test

Diseases (25)
Screening/Initial Testing (1)
Ovarian cancer screening
7
Note: May be considered in patients with suspected or known familial cancer syndrome(s). Typically testing is every 6 months beginning at age 30.
Diagnostic Testing (11)
Endometriosis
6
Note: CA-125 may be increased in patients with endometriosis but it is not specific (J Obstet Gynaecol Can 2024 May;46(5):102450).
Portal vein thrombosis
6
Note: If occult malignancy is suspected.
Secondary hypothyroidism
5
Note: Might be elevated in hypothyroidsm. BMJ 2002 Oct 26;325(7370):946
Disease Management Testing (3)
Other Supportive/Alternative Tests (10)
Actinomycosis
6
Note: Elevated CA-125 is seen in patients with pelvic actinomycosis.
Cancer of unknown primary site
6
Note: Aid in diagnosis and management of ovarian cancer.
Benign neoplasm of liver and/or biliary ducts
5
Note: Not specific, but supportive of diagnosis and treatment.
Hepatocellular carcinoma
5
Note: Not specific, but might be supportive for diagnosis and treatment.
Malignant neoplasm of testis (Testicular cancer)
5
Note: Not specific for testicular cancer, but might be supportive for diagnosis and treatment.
Malignant neoplasm, female breast
5
Note: Not specific for breast cancer, but might be supportive for diagnosis and treatment.
Malignant neoplasm, renal pelvis (kidney)
5
Note: Not specific for kidney cancer, but might be supportive for diagnosis and treatment.
Malignant neoplasm, uterine cervix (cervical cancer)
5
Note: Not specific, but supportive for diagnosis and treatment.
Mesothelioma (Malignant pleural mesothelioma)
5
Note: Not specific for mesothelioma, but can be supportive.
Neoplasm of soft tissue (soft tissue sarcomas)
5
Note: Not specific, but supportive.