CA 125 is a cell surface protein often found on ovarian cancer cells and in some normal tissues. It is one of the protein antigens that has been associated with the presence of various cancers, but is most often positive in ovarian cancer. CA 125 concentrations may also be elevated in other types of non-cancerous conditions, including menstruation, pregnancy, and pelvic inflammatory disease. CA 125 is a useful tumor marker for evaluating therapy and monitoring disease status in ovarian cancer patients. As the levels decrease it is an indication that the therapy or treatment is working. Post-operatively, the CA 125 concentration correlates with tumor bulk and is a prognostic indicator of clinical outcome. It has been reported that patients with levels exceeding 35 U/mL have the highest risk for clinical recurrence. CA 125 is not useful as a screening mechanism because it is elevated in many non-cancerous conditions, although women that are at higher risk due to family history or other reasons are usually tested regularly as a precautionary method.
Measured serially, serum CA 125 concentration typically corresponds with disease progression or regression. The rate of change in CA 125 is also highly prognostic. A rapid decrease in the level of CA 125 indicates a positive response to treatment. Elevated levels of CA 125 after the third course of primary chemotherapy are typically predictive of poor outcomes.
Note: Normal levels do not exclude recurrent malignancy.
<30 U/mL
Enzyme Immunoassay, ELISA
Carcinoembryonic antigen (CEA), CA 15-3, CA 19-9, Follicle Stimulating Hormone, Luteinizing Hormone, HCG, Progesterone, HE4.
1-3 days.
86304 | $ 20.81 |
C25 | Malignant neoplasm of pancreas |
C25.0 | Malignant neoplasm of head of pancreas |
C25.1 | Malignant neoplasm of body of pancreas |
C25.2 | Malignant neoplasm of tail of pancreas |
C25.7 | Malignant neoplasm of other parts of pancreas |
C25.9 | Malignant neoplasm of pancreas, unspecified |
C48 | Malignant neoplasm of retroperitoneum and peritoneum |
C48.0 | Malignant neoplasm of retroperitoneum |
C48.1 | Malignant neoplasm of specified parts of peritoneum |
C48.2 | Malignant neoplasm of peritoneum, unspecified |
C48.8 | Malignant neoplasm of overlapping sites of retroperitoneum and peritoneum |
C54 | Malignant neoplasm of corpus uteri |
C54.0 | Malignant neoplasm of isthmus uteri |
C54.1 | Malignant neoplasm of endometrium |
C54.2 | Malignant neoplasm of myometrium |
C54.3 | Malignant neoplasm of fundus uteri |
C54.9 | Malignant neoplasm of corpus uteri, unspecified |
C56 | Malignant neoplasm of ovary |
C56.1 | Malignant neoplasm of right ovary |
C56.2 | Malignant neoplasm of left ovary |
C56.9 | Malignant neoplasm of unspecified ovary |
C57 | Malignant neoplasm of other and unspecified female genital organs |
C57.00 | Malignant neoplasm of unspecified fallopian tube |
C57.01 | Malignant neoplasm of right fallopian tube |
C57.02 | Malignant neoplasm of left fallopian tube |
C78 | Secondary malignant neoplasm of respiratory and digestive organs |
C78.0 | Secondary malignant neoplasm of lung |
C78.00 | Secondary malignant neoplasm of unspecified lung |
C78.2 | Secondary malignant neoplasm of pleura |
C78.4 | Secondary malignant neoplasm of small intestine |
C78.89 | Secondary malignant neoplasm of other digestive organs |
C79 | Secondary malignant neoplasm of other and unspecified sites |
C79.00 | Secondary malignant neoplasm of unspecified kidney and renal pelvis |
C79.11 | Secondary malignant neoplasm of bladder |
C79.2 | Secondary malignant neoplasm of skin |
C79.31 | Secondary malignant neoplasm of brain |
C79.49 | Secondary malignant neoplasm of other parts of nervous system |
C79.51 | Secondary malignant neoplasm of bone |
C79.52 | Secondary malignant neoplasm of bone marrow |
C79.6 | Secondary malignant neoplasm of ovary |
C79.7 | Secondary malignant neoplasm of adrenal gland |
C79.81 | Secondary malignant neoplasm of breast |
C79.82 | Secondary malignant neoplasm of genital organs |
C79.89 | Secondary malignant neoplasm of other specified sites |
C79.9 | Secondary malignant neoplasm of unspecified site |
C80 | Malignant neoplasm without specification of site |
C80.0 | Disseminated malignant neoplasm, unspecified |
C80.1 | Malignant (primary) neoplasm, unspecified |
C80.2 | Malignant neoplasm associated with transplanted organ |
D21 | Other benign neoplasms of connective and other soft tissue |
D27 | Benign neoplasm of ovary |
D27.0 | Benign neoplasm of right ovary |
D27.1 | Benign neoplasm of left ovary |
D27.9 | Benign neoplasm of unspecified ovary |
E00 | Congenital iodine-deficiency syndrome |
E02 | Subclinical iodine-deficiency hypothyroidism |
E03 | Other hypothyroidism |
E03.8 | Other specified hypothyroidism |
E03.9 | Hypothyroidism, unspecified |
E89.0 | Postprocedural hypothyroidism |
N80 | Endometriosis |
N80.0 | Endometriosis of uterus |
N80.9 | Endometriosis, unspecified |
N85 | Other noninflammatory disorders of uterus, except cervix |
N85.02 | Endometrial intraepithelial neoplasia [EIN] |
R97 | Abnormal tumor markers |
R97.0 | Elevated carcinoembryonic antigen [CEA] |
R97.1 | Elevated cancer antigen 125 [CA 125] |
Z12.73 | Encounter for screening for malignant neoplasm of ovary |
Z12.8 | Encounter for screening for malignant neoplasm of other sites |
Z12.89 | Encounter for screening for malignant neoplasm of other sites |
Z51.1 | Encounter for antineoplastic chemotherapy and immunotherapy |
Z85 | Personal history of malignant neoplasm |
Z85.07 | Personal history of malignant neoplasm of pancreas |
Z85.42 | Personal history of malignant neoplasm of other parts of uterus |
Z85.43 | Personal history of malignant neoplasm of ovary |
Z85.44 | Personal history of malignant neoplasm of other female genital organs |
C25.0 | Malignant neoplasm of head of pancreas |
C25.1 | Malignant neoplasm of body of pancreas |
C25.2 | Malignant neoplasm of tail of pancreas |
C25.3 | Malignant neoplasm of pancreatic duct |
C25.4 | Malignant neoplasm of endocrine pancreas |
C25.7 | Malignant neoplasm of other parts of pancreas |
C25.8 | Malignant neoplasm of overlapping sites of pancreas |
C25.9 | Malignant neoplasm of pancreas, unspecified |
C48.0 | Malignant neoplasm of retroperitoneum |
C48.1 | Malignant neoplasm of specified parts of peritoneum |
C48.2 | Malignant neoplasm of peritoneum, unspecified |
C48.8 | Malignant neoplasm of overlapping sites of retroperitoneum and peritoneum |
C54.0 | Malignant neoplasm of isthmus uteri |
C54.1 | Malignant neoplasm of endometrium |
C54.2 | Malignant neoplasm of myometrium |
C54.3 | Malignant neoplasm of fundus uteri |
C54.8 | Malignant neoplasm of overlapping sites of corpus uteri |
C54.9 | Malignant neoplasm of corpus uteri, unspecified |
C56.1 | Malignant neoplasm of right ovary |
C56.2 | Malignant neoplasm of left ovary |
C56.9 | Malignant neoplasm of unspecified ovary |
C57.0 | Malignant neoplasm of fallopian tube |
C57.00 | Malignant neoplasm of unspecified fallopian tube |
C57.01 | Malignant neoplasm of right fallopian tube |
C57.02 | Malignant neoplasm of left fallopian tube |
C57.1 | Malignant neoplasm of broad ligament |
C57.10 | Malignant neoplasm of unspecified broad ligament |
C57.11 | Malignant neoplasm of right broad ligament |
C57.12 | Malignant neoplasm of left broad ligament |
C57.2 | Malignant neoplasm of round ligament |
C57.20 | Malignant neoplasm of unspecified round ligament |
C57.21 | Malignant neoplasm of right round ligament |
C57.22 | Malignant neoplasm of left round ligament |
C57.3 | Malignant neoplasm of parametrium |
C57.4 | Malignant neoplasm of uterine adnexa, unspecified |
C57.7 | Malignant neoplasm of other specified female genital organs |
C57.8 | Malignant neoplasm of overlapping sites of female genital organs |
C57.9 | Malignant neoplasm of female genital organ, unspecified |
C78.0 | Secondary malignant neoplasm of lung |
C78.00 | Secondary malignant neoplasm of unspecified lung |
C78.01 | Secondary malignant neoplasm of right lung |
C78.02 | Secondary malignant neoplasm of left lung |
C78.1 | Secondary malignant neoplasm of mediastinum |
C78.2 | Secondary malignant neoplasm of pleura |
C78.3 | Secondary malignant neoplasm of other and unspecified respiratory organs |
C78.30 | Secondary malignant neoplasm of unspecified respiratory organ |
C78.39 | Secondary malignant neoplasm of other respiratory organs |
C78.4 | Secondary malignant neoplasm of small intestine |
C78.5 | Secondary malignant neoplasm of large intestine and rectum |
C78.6 | Secondary malignant neoplasm of retroperitoneum and peritoneum |
C78.7 | Secondary malignant neoplasm of liver and intrahepatic bile duct |
C78.8 | Secondary malignant neoplasm of other and unspecified digestive organs |
C78.80 | Secondary malignant neoplasm of unspecified digestive organ |
C78.89 | Secondary malignant neoplasm of other digestive organs |
C79.0 | Secondary malignant neoplasm of kidney and renal pelvis |
C79.00 | Secondary malignant neoplasm of unspecified kidney and renal pelvis |
C79.01 | Secondary malignant neoplasm of right kidney and renal pelvis |
C79.02 | Secondary malignant neoplasm of left kidney and renal pelvis |
C79.1 | Secondary malignant neoplasm of bladder and other and unspecified urinary organs |
C79.10 | Secondary malignant neoplasm of unspecified urinary organs |
C79.11 | Secondary malignant neoplasm of bladder |
C79.19 | Secondary malignant neoplasm of other urinary organs |
C79.2 | Secondary malignant neoplasm of skin |
C79.3 | Secondary malignant neoplasm of brain and cerebral meninges |
C79.31 | Secondary malignant neoplasm of brain |
C79.32 | Secondary malignant neoplasm of cerebral meninges |
C79.4 | Secondary malignant neoplasm of other and unspecified parts of nervous system |
C79.40 | Secondary malignant neoplasm of unspecified part of nervous system |
C79.49 | Secondary malignant neoplasm of other parts of nervous system |
C79.5 | Secondary malignant neoplasm of bone and bone marrow |
C79.51 | Secondary malignant neoplasm of bone |
C79.52 | Secondary malignant neoplasm of bone marrow |
C79.6 | Secondary malignant neoplasm of ovary |
C79.60 | Secondary malignant neoplasm of unspecified ovary |
C79.61 | Secondary malignant neoplasm of right ovary |
C79.62 | Secondary malignant neoplasm of left ovary |
C79.7 | Secondary malignant neoplasm of adrenal gland |
C79.70 | Secondary malignant neoplasm of unspecified adrenal gland |
C79.71 | Secondary malignant neoplasm of right adrenal gland |
C79.72 | Secondary malignant neoplasm of left adrenal gland |
C79.8 | Secondary malignant neoplasm of other specified sites |
C79.81 | Secondary malignant neoplasm of breast |
C79.82 | Secondary malignant neoplasm of genital organs |
C79.89 | Secondary malignant neoplasm of other specified sites |
C79.9 | Secondary malignant neoplasm of unspecified site |
C80.0 | Disseminated malignant neoplasm, unspecified |
C80.1 | Malignant (primary) neoplasm, unspecified |
C80.2 | Malignant neoplasm associated with transplanted organ |
D13.6 | Benign neoplasm of pancreas |
D21.0 | Benign neoplasm of connective and other soft tissue of head, face and neck |
D21.1 | Benign neoplasm of connective and other soft tissue of upper limb, including shoulder |
D21.10 | Benign neoplasm of connective and other soft tissue of unspecified upper limb, including shoulder |
D21.11 | Benign neoplasm of connective and other soft tissue of right upper limb, including shoulder |
D21.12 | Benign neoplasm of connective and other soft tissue of left upper limb, including shoulder |
D21.2 | Benign neoplasm of connective and other soft tissue of lower limb, including hip |
D21.20 | Benign neoplasm of connective and other soft tissue of unspecified lower limb, including hip |
D21.21 | Benign neoplasm of connective and other soft tissue of right lower limb, including hip |
D21.22 | Benign neoplasm of connective and other soft tissue of left lower limb, including hip |
D21.3 | Benign neoplasm of connective and other soft tissue of thorax |
D21.4 | Benign neoplasm of connective and other soft tissue of abdomen |
D21.5 | Benign neoplasm of connective and other soft tissue of pelvis |
D21.6 | Benign neoplasm of connective and other soft tissue of trunk, unspecified |
D21.9 | Benign neoplasm of connective and other soft tissue, unspecified |
D27.0 | Benign neoplasm of right ovary |
D27.1 | Benign neoplasm of left ovary |
D27.9 | Benign neoplasm of unspecified ovary |
D39.1 | Neoplasm of uncertain behavior of ovary |
D39.10 | Neoplasm of uncertain behavior of unspecified ovary |
D39.11 | Neoplasm of uncertain behavior of right ovary |
D39.12 | Neoplasm of uncertain behavior of left ovary |
D61.810 | Antineoplastic chemotherapy induced pancytopenia |
D64.81 | Anemia due to antineoplastic chemotherapy |
D70.1 | Agranulocytosis secondary to cancer chemotherapy |
E00.0 | Congenital iodine-deficiency syndrome, neurological type |
E00.1 | Congenital iodine-deficiency syndrome, myxedematous type |
E00.2 | Congenital iodine-deficiency syndrome, mixed type |
E00.9 | Congenital iodine-deficiency syndrome, unspecified |
E03.0 | Congenital hypothyroidism with diffuse goiter |
E03.1 | Congenital hypothyroidism without goiter |
E03.2 | Hypothyroidism due to medicaments and other exogenous substances |
E03.3 | Postinfectious hypothyroidism |
E03.4 | Atrophy of thyroid (acquired) |
E03.5 | Myxedema coma |
E03.8 | Other specified hypothyroidism |
E03.9 | Hypothyroidism, unspecified |
N80.0 | Endometriosis of uterus |
N80.1 | Endometriosis of ovary |
N80.2 | Endometriosis of fallopian tube |
N80.3 | Endometriosis of pelvic peritoneum |
N80.4 | Endometriosis of rectovaginal septum and vagina |
N80.5 | Endometriosis of intestine |
N80.6 | Endometriosis in cutaneous scar |
N80.8 | Other endometriosis |
N80.9 | Endometriosis, unspecified |
N85.0 | Endometrial hyperplasia |
N85.00 | Endometrial hyperplasia, unspecified |
N85.01 | Benign endometrial hyperplasia |
N85.02 | Endometrial intraepithelial neoplasia [EIN] |
N85.2 | Hypertrophy of uterus |
N85.3 | Subinvolution of uterus |
N85.4 | Malposition of uterus |
N85.5 | Inversion of uterus |
N85.6 | Intrauterine synechiae |
N85.7 | Hematometra |
N85.8 | Other specified noninflammatory disorders of uterus |
N85.9 | Noninflammatory disorder of uterus, unspecified |
P04.11 | Newborn affected by maternal antineoplastic chemotherapy |
R97.0 | Elevated carcinoembryonic antigen [CEA] |
R97.1 | Elevated cancer antigen 125 [CA 125] |
R97.2 | Elevated prostate specific antigen [PSA] |
R97.20 | Elevated prostate specific antigen [PSA] |
R97.21 | Rising PSA following treatment for malignant neoplasm of prostate |
R97.8 | Other abnormal tumor markers |
T80.810 | Extravasation of vesicant antineoplastic chemotherapy |
T80.810A | Extravasation of vesicant antineoplastic chemotherapy, initial encounter |
T80.810D | Extravasation of vesicant antineoplastic chemotherapy, subsequent encounter |
T80.810S | Extravasation of vesicant antineoplastic chemotherapy, sequela |
Z12.73 | Encounter for screening for malignant neoplasm of ovary |
Z15.02 | Genetic susceptibility to malignant neoplasm of ovary |
Z51.1 | Encounter for antineoplastic chemotherapy and immunotherapy |
Z51.11 | Encounter for antineoplastic chemotherapy |
Z80.41 | Family history of malignant neoplasm of ovary |
Z85.0 | Personal history of malignant neoplasm of digestive organs |
Z85.00 | Personal history of malignant neoplasm of unspecified digestive organ |
Z85.01 | Personal history of malignant neoplasm of esophagus |
Z85.02 | Personal history of malignant neoplasm of stomach |
Z85.020 | Personal history of malignant carcinoid tumor of stomach |
Z85.028 | Personal history of other malignant neoplasm of stomach |
Z85.03 | Personal history of malignant neoplasm of large intestine |
Z85.030 | Personal history of malignant carcinoid tumor of large intestine |
Z85.038 | Personal history of other malignant neoplasm of large intestine |
Z85.04 | Personal history of malignant neoplasm of rectum, rectosigmoid junction, and anus |
Z85.040 | Personal history of malignant carcinoid tumor of rectum |
Z85.048 | Personal history of other malignant neoplasm of rectum, rectosigmoid junction, and anus |
Z85.05 | Personal history of malignant neoplasm of liver |
Z85.06 | Personal history of malignant neoplasm of small intestine |
Z85.060 | Personal history of malignant carcinoid tumor of small intestine |
Z85.068 | Personal history of other malignant neoplasm of small intestine |
Z85.07 | Personal history of malignant neoplasm of pancreas |
Z85.09 | Personal history of malignant neoplasm of other digestive organs |
Z85.1 | Personal history of malignant neoplasm of trachea, bronchus and lung |
Z85.11 | Personal history of malignant neoplasm of bronchus and lung |
Z85.110 | Personal history of malignant carcinoid tumor of bronchus and lung |
Z85.118 | Personal history of other malignant neoplasm of bronchus and lung |
Z85.12 | Personal history of malignant neoplasm of trachea |
Z85.2 | Personal history of malignant neoplasm of other respiratory and intrathoracic organs |
Z85.20 | Personal history of malignant neoplasm of unspecified respiratory organ |
Z85.21 | Personal history of malignant neoplasm of larynx |
Z85.22 | Personal history of malignant neoplasm of nasal cavities, middle ear, and accessory sinuses |
Z85.23 | Personal history of malignant neoplasm of thymus |
Z85.230 | Personal history of malignant carcinoid tumor of thymus |
Z85.238 | Personal history of other malignant neoplasm of thymus |
Z85.29 | Personal history of malignant neoplasm of other respiratory and intrathoracic organs |
Z85.3 | Personal history of malignant neoplasm of breast |
Z85.4 | Personal history of malignant neoplasm of genital organs |
Z85.40 | Personal history of malignant neoplasm of unspecified female genital organ |
Z85.41 | Personal history of malignant neoplasm of cervix uteri |
Z85.42 | Personal history of malignant neoplasm of other parts of uterus |
Z85.43 | Personal history of malignant neoplasm of ovary |
Z85.44 | Personal history of malignant neoplasm of other female genital organs |
Z85.45 | Personal history of malignant neoplasm of unspecified male genital organ |
Z85.46 | Personal history of malignant neoplasm of prostate |
Z85.47 | Personal history of malignant neoplasm of testis |
Z85.48 | Personal history of malignant neoplasm of epididymis |
Z85.49 | Personal history of malignant neoplasm of other male genital organs |
Z85.5 | Personal history of malignant neoplasm of urinary tract |
Z85.50 | Personal history of malignant neoplasm of unspecified urinary tract organ |
Z85.51 | Personal history of malignant neoplasm of bladder |
Z85.52 | Personal history of malignant neoplasm of kidney |
Z85.520 | Personal history of malignant carcinoid tumor of kidney |
Z85.528 | Personal history of other malignant neoplasm of kidney |
Z85.53 | Personal history of malignant neoplasm of renal pelvis |
Z85.54 | Personal history of malignant neoplasm of ureter |
Z85.59 | Personal history of malignant neoplasm of other urinary tract organ |
Z85.6 | Personal history of leukemia |
Z85.7 | Personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues |
Z85.71 | Personal history of Hodgkin lymphoma |
Z85.72 | Personal history of non-Hodgkin lymphomas |
Z85.79 | Personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues |
Z85.8 | Personal history of malignant neoplasms of other organs and systems |
Z85.81 | Personal history of malignant neoplasm of lip, oral cavity, and pharynx |
Z85.810 | Personal history of malignant neoplasm of tongue |
Z85.818 | Personal history of malignant neoplasm of other sites of lip, oral cavity, and pharynx |
Z85.819 | Personal history of malignant neoplasm of unspecified site of lip, oral cavity, and pharynx |
Z85.82 | Personal history of malignant neoplasm of skin |
Z85.820 | Personal history of malignant melanoma of skin |
Z85.821 | Personal history of Merkel cell carcinoma |
Z85.828 | Personal history of other malignant neoplasm of skin |
Z85.83 | Personal history of malignant neoplasm of bone and soft tissue |
Z85.830 | Personal history of malignant neoplasm of bone |
Z85.831 | Personal history of malignant neoplasm of soft tissue |
Z85.84 | Personal history of malignant neoplasm of eye and nervous tissue |
Z85.840 | Personal history of malignant neoplasm of eye |
Z85.841 | Personal history of malignant neoplasm of brain |
Z85.848 | Personal history of malignant neoplasm of other parts of nervous tissue |
Z85.85 | Personal history of malignant neoplasm of endocrine glands |
Z85.850 | Personal history of malignant neoplasm of thyroid |
Z85.858 | Personal history of malignant neoplasm of other endocrine glands |
Z85.89 | Personal history of malignant neoplasm of other organs and systems |
Z85.9 | Personal history of malignant neoplasm, unspecified |
Z92.21 | Personal history of antineoplastic chemotherapy |