Iron, Serum
Medical Test

Diseases (115)
Screening/Initial Testing (3)
Diagnostic Testing (45)
Anemia, NOS
10
Note:
Liver Disease
9
Note: Rule out iron liver disease.
Alopecia
8
Note: Rule out iron deficiency.
Chronic gastritis
8
Note: Evaluate for possible iron deficiency secondary to achlorhydria. Especially if anemia is present.
Chronic liver disease
8
Note: Rule out liver disease due to iron overload, hemochromatosis.
Gastrointestinal hemorrhage
8
Note: If anemia is present, esp. if microcytic/hypochromic.
Hepatic steatosis (fatty liver)
8
Note: Rule out hemochromatosis.
Jaundice
8
Note:
Chronic hepatitis
7
Note: Rule out hemochromatosis.
Pernicious anemia
7
Note: If patient is diagnosed with folate or Vit. B12 deficiency but the MCV is normal or low
Viral hepatitis type C
7
Note: To rule out hemochromatosis
Acute hepatic failure
6
Note: Rule out iron load, hemochromatosis.
Autoimmune hemolytic anemia
6
Note: Rule out iron deficiency anemia.
Budd-Chiari syndrome
6
Note: Rule out hemochromatosis.
Chronic myeloid leukemia (CML)
6
Note: If anemia present.
Chronic myelomonocytic leukemia
6
Note: To evaluate and monitor anemia.
Disease Management Testing (23)
Anemia, NOS
10
Note: To monitor iron related therapy in iron related deficiency anemia.
Pernicious anemia
9
Note: If patient has been previously shown to have concommitant iron deficiency
Pregnancy without complications
8
Note: If anemia is seen.
Ulcerative colitis
8
Note: Rule out iron deficiency if anemia is present.
Chronic liver disease
7
Note: If chronic liver disease cased by iron overload.
Inflammatory bowel disease
7
Note: If abnormally low?
Acute myeloid leukemia (AML)
6
Note: If hemoglobin is low due to anemia.
Follicular lymphoma
6
Note: If hemoglobin is low due anemia.
Peripheral T-cell lymphoma
6
Note: If hemoglobin is low due to anemia.
Other Supportive/Alternative Tests (44)
Diabetes mellitus type 2
6
Note: Rule out iron deficiency anemia.
Acute lymphoid ( lymphoblastic) leukemia (ALL)
5
Note: If hemoglobin is low due to anemia.
Adult T-cell leukemia/lymphoma
5
Note: If hemoglobin is low due to anemia.
Adult preventative health screening
5
Note: I hemoglobin is low.
Alveolar rhabdomyosarcoma
5
Note: If hemoglobin is low due to anemia.
Anaplastic large cell lymphoma
5
Note: If hemoglobin is low due to anemia.
Benign neoplasm of liver and/or biliary ducts
5
Note: If hemoglobin is low due to anemia.
Burkitt lymphoma
5
Note: If hemoglobin is low due to anemia.
Cancer of unknown primary site
5
Note: If hemoglobin is low due to anemia.
Diffuse large B-cell lymphoma
5
Note: If hemoglobin is low due to anemia.
Geriatric health maintenance
5
Note: If hemoglobin is low.
Hepatocellular carcinoma
5
Note: If hemoglobin is low due to anemia.
Kaposi's sarcoma
5
Note: If hemoglobin is low due to anemia.
Malignant Melanoma
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm of lung
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm of testis (Testicular cancer)
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm of thymus
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm, adrenal gland
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm, brain
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm, endometrium (endometrial cancer)
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm, extrahepatic bile duct
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm, female breast
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm, ovary
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm, pancreas
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm, pituitary gland
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm, renal pelvis (kidney)
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm, stomach
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm, thyroid gland
5
Note: If hemoglobin is low due to anemia.
Malignant neoplasm, uterine cervix (cervical cancer)
5
Note: If hemoglobin is low due to anemia.
Mantle cell lymphoma
5
Note: If hemoglobin is low due to anemia.
Merkel Cell Carcinoma
5
Note: If hemoglobin is low due to anemia.
Multiple myeloma
5
Note: If hemoglobin is low due to anemia.
Neoplasm of soft tissue (soft tissue sarcomas)
5
Note: If hemoglobin is low due to anemia.
Neuroendocrine Neoplasms (Carcinoid Tumors)
5
Note: If hemoglobin is low due to anemia.
Non-Hodgkin lymphoma
5
Note: If hemoglobin is low due to anemia.
Non-small cell carcinoma (NSCLC), lung
5
Note: If hemoglobin is low due to anemia.
Primary myelofibrosis (PMF)
5
Note: If hemoglobin is low due to anemia.

Overview

Iron is a structural part of hemoglobin, which functions to transport oxygen. Ingested iron is mainly absorbed in the form of Fe2 + in the duodenum and upper jejunum. Absorbed iron is then transported in blood plasma by transferrin-iron complexes. A maximum of 2 Fe2 + ions per transferrin molecule can be transported. Serum iron is almost completely bound to transferrin.

Testing for iron (non-heme) levels is used in the diagnosis and treatment of diseases such as iron deficiency anemia and hemochromatosis. Hemochromatosis is a disease associated with iron deposits in tissues, usually deposited in the form of iron-containing pigments such as hemosiderin and hemofuscin. Disease is characterized by pigmentation of the skin and chronic renal disease. In addition, iron testing can be useful in the diagnosis and monitoring of microcytic anemias (e.g. due to iron metabolism disorders and hemoglobinopathies), macrocytic anemias (e.g. due to vitamin B12 deficiency, folic acid deficiency, and drug-induced metabolic disorders of unknown origin), normocytic anemias such as anemia of chronic renal disease (erythropoetin deficiency), hemolytic anemia, bone marrow disease, and toxic bone marrow damage. Percent iron saturation should also be obtained because it is more helpful than serum iron in estimating iron stores and evaluating for iron deficiency anemia.

Clinical Utility

  • Differential diagnosis of anemia, especially with hypochromia and/or low red blood cell MCV
  • As an aid in diagnosis of thalassemia and sideroblastic anemia
  • As an aid in diagnosis of hemochromatosis
  • Diagnosis of iron deficiency

Interpretation

Increased in:

  • Hemosiderosis due to increased iron uptake
  • Multiple transfusions
  • Hemolytic anemia
  • Pernicious anemia
  • Aplastic or hypoplastic anemia
  • Viral hepatitis
  • Lead poisoning
  • Thalassemias
  • Some drugs: estrogens, ethanol, oral contraceptives

Decreased in:

  • Iron deficiency
  • Nephrotic syndrome
  • Chronic renal failure
  • Many infections
  • Active hematopoiesis
  • Remission of pernicious anemia
  • Some malignancies (some carcinomas)
  • Gastrectomy
  • Nutritional (children and premenopausal women)
  • Pregnancy
  • Chronic blood loss due to bleeding

Reference Ranges

Units mcg/dL umol/L
Newborn 100-250 17.9-44.8
Infant 40-100 7.2-17.9
Child 50-120 9.0-21.5
Intoxicated child 280-2550 50.1-456.5
Fatally poisoned child 1800 322.2
Adult M 65-175 11.6-31.3
Adult F 50-170 9.0-30.4

Methodology
Timed Endpoint Spectroscopy Method.

Specimen Collection

Serum (SST) or Plasma Heparin (Green). 

Draw blood before other specimens that require anticoagulated tubes. Reject hemolyzed samples.

Stability

  • Ambient: 3-5 days
  • Refrigerated: 7-14 days
  • Frozen: 28 days

Separate serum of Plasma within 45 minutes of collection.

Additional Testing

Complete Blood Count with RBC Indices, Vitamin B12, Folate, Ferritin, TIBC, Transferrin, Transferrin Receptor, Erythropoietin, Hemochromatosis Mutation, Lead Level, Occult Blood, Porphyrins Urine.

CPT
83540$6.47
83550$8.74

ICD10
  • AK - Alaska
  • AL - Alabama
  • AR - Arkansas
  • AS - American Samoa
  • AZ - Arizona
  • CA - California - Entire State
  • CO - Colorado
  • CT - Connecticut
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  • LA - Louisiana
  • MA - Massachusetts
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  • MO - Missouri - Entire State
  • MS - Mississippi
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  • NC - North Carolina
  • ND - North Dakota
  • NE - Nebraska
  • NH - New Hampshire
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  • NM - New Mexico
  • NV - Nevada
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  • OH - Ohio
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  • VI - Virgin Islands
  • VT - Vermont
  • WA - Washington
  • WI - Wisconsin
  • WV - West Virginia
  • WY - Wyoming
  • CNMI - Northern Mariana Islands
  • EM - Missouri - Northeastern & Southern
  • WM - Missouri - Northwestern
  • DN - New York - Downstate
  • QN - New York - Queens
  • UN - New York - Upstate
  • NF - California - Northern
  • SF - California - Southern
Showing results for all states.
Filter:
ICD10 CODE AND DESCRIPTIONLCD CODENCD CODE
A08 - Viral and other specified intestinal infections——
A36.81 - Diphtheritic cardiomyopathy——
A51.32 - Syphilitic alopecia——
B15 - Acute hepatitis A——
B16 - Acute hepatitis B——
B16.1 - Acute hepatitis B with delta-agent without hepatic coma——
B17 - Other acute viral hepatitis——
B17.1 - Acute hepatitis C——
B17.10 - Acute hepatitis C without hepatic coma——
B17.11 - Acute hepatitis C with hepatic coma——
B17.2 - Acute hepatitis E——
B18 - Chronic viral hepatitis——
B18.0 - Chronic viral hepatitis B with delta-agent——
B18.1 - Chronic viral hepatitis B without delta-agent——
B18.2 - Chronic viral hepatitis C——
B18.8 - Other chronic viral hepatitis——
B18.9 - Chronic viral hepatitis, unspecified——
B19 - Unspecified viral hepatitis——
B19.0 - Unspecified viral hepatitis with hepatic coma——
B19.1 - Unspecified viral hepatitis B——
B19.10 - Unspecified viral hepatitis B without hepatic coma——
B19.11 - Unspecified viral hepatitis B with hepatic coma——
B19.2 - Unspecified viral hepatitis C——
B19.20 - Unspecified viral hepatitis C without hepatic coma——
B19.21 - Unspecified viral hepatitis C with hepatic coma——
B19.9 - Unspecified viral hepatitis without hepatic coma——
B25.1 - Cytomegaloviral hepatitis——
B26.81 - Mumps hepatitis——
B33.24 - Viral cardiomyopathy——
B58.1 - Toxoplasma hepatitis——
B94.2 - Sequelae of viral hepatitis——
B96.81 - Helicobacter pylori [H. pylori] as the cause of diseases classified elsewhere——
C00 - Malignant neoplasm of lip——
C00.9 - Malignant neoplasm of lip, unspecified——
C01 - Malignant neoplasm of base of tongue——
C02 - Malignant neoplasm of other and unspecified parts of tongue——
C02.9 - Malignant neoplasm of tongue, unspecified——
C03 - Malignant neoplasm of gum——
C03.0 - Malignant neoplasm of upper gum——
C03.1 - Malignant neoplasm of lower gum——
C03.9 - Malignant neoplasm of gum, unspecified——
C04 - Malignant neoplasm of floor of mouth——
C04.0 - Malignant neoplasm of anterior floor of mouth——
C04.1 - Malignant neoplasm of lateral floor of mouth——
C04.8 - Malignant neoplasm of overlapping sites of floor of mouth——
C04.9 - Malignant neoplasm of floor of mouth, unspecified——
C05 - Malignant neoplasm of palate——
C05.9 - Malignant neoplasm of palate, unspecified——
C06 - Malignant neoplasm of other and unspecified parts of mouth——
C06.0 - Malignant neoplasm of cheek mucosa——

Additional ICD10
  • AK - Alaska
  • AL - Alabama
  • AR - Arkansas
  • AS - American Samoa
  • AZ - Arizona
  • CA - California - Entire State
  • CO - Colorado
  • CT - Connecticut
  • DC - District of Columbia
  • DE - Delaware
  • FL - Florida
  • GA - Georgia
  • GU - Guam
  • HI - Hawaii
  • IA - Iowa
  • ID - Idaho
  • IL - Illinois
  • IN - Indiana
  • KS - Kansas
  • KY - Kentucky
  • LA - Louisiana
  • MA - Massachusetts
  • MD - Maryland
  • ME - Maine
  • MI - Michigan
  • MN - Minnesota
  • MO - Missouri - Entire State
  • MS - Mississippi
  • MT - Montana
  • NC - North Carolina
  • ND - North Dakota
  • NE - Nebraska
  • NH - New Hampshire
  • NJ - New Jersey
  • NM - New Mexico
  • NV - Nevada
  • NY - New York - Entire State
  • OH - Ohio
  • OK - Oklahoma
  • OR - Oregon
  • PA - Pennsylvania
  • PR - Puerto Rico
  • RI - Rhode Island
  • SC - South Carolina
  • SD - South Dakota
  • TN - Tennessee
  • TX - Texas
  • UT - Utah
  • VA - Virginia
  • VI - Virgin Islands
  • VT - Vermont
  • WA - Washington
  • WI - Wisconsin
  • WV - West Virginia
  • WY - Wyoming
  • CNMI - Northern Mariana Islands
  • EM - Missouri - Northeastern & Southern
  • WM - Missouri - Northwestern
  • DN - New York - Downstate
  • QN - New York - Queens
  • UN - New York - Upstate
  • NF - California - Northern
  • SF - California - Southern
Showing results for all states.
Filter:
ICD10 CODE AND DESCRIPTIONLCD CODENCD CODE
A06.4 - Amebic liver abscess——
A08.0 - Rotaviral enteritis——
A08.1 - Acute gastroenteropathy due to Norwalk agent and other small round viruses——
A08.11 - Acute gastroenteropathy due to Norwalk agent——
A08.19 - Acute gastroenteropathy due to other small round viruses——
A08.2 - Adenoviral enteritis——
A08.3 - Other viral enteritis——
A08.31 - Calicivirus enteritis——
A08.32 - Astrovirus enteritis——
A08.39 - Other viral enteritis——
A08.4 - Viral intestinal infection, unspecified——
A08.8 - Other specified intestinal infections——
A51.45 - Secondary syphilitic hepatitis——
A52.74 - Syphilis of liver and other viscera——
B00.81 - Herpesviral hepatitis——
B15.0 - Hepatitis A with hepatic coma——
B15.9 - Hepatitis A without hepatic coma——
B16.0 - Acute hepatitis B with delta-agent with hepatic coma——
B16.1 - Acute hepatitis B with delta-agent without hepatic coma——
B16.2 - Acute hepatitis B without delta-agent with hepatic coma——
B16.9 - Acute hepatitis B without delta-agent and without hepatic coma——
B17.0 - Acute delta-(super) infection of hepatitis B carrier——
B17.1 - Acute hepatitis C——
B17.10 - Acute hepatitis C without hepatic coma——
B17.11 - Acute hepatitis C with hepatic coma——
B17.2 - Acute hepatitis E——
B17.8 - Other specified acute viral hepatitis——
B17.9 - Acute viral hepatitis, unspecified——
B18.0 - Chronic viral hepatitis B with delta-agent——
B18.1 - Chronic viral hepatitis B without delta-agent——
B18.2 - Chronic viral hepatitis C——
B18.8 - Other chronic viral hepatitis——
B18.9 - Chronic viral hepatitis, unspecified——
B19.0 - Unspecified viral hepatitis with hepatic coma——
B19.1 - Unspecified viral hepatitis B——
B19.10 - Unspecified viral hepatitis B without hepatic coma——
B19.11 - Unspecified viral hepatitis B with hepatic coma——
B19.2 - Unspecified viral hepatitis C——
B19.20 - Unspecified viral hepatitis C without hepatic coma——
B19.21 - Unspecified viral hepatitis C with hepatic coma——
B19.9 - Unspecified viral hepatitis without hepatic coma——
B25.1 - Cytomegaloviral hepatitis——
B26.81 - Mumps hepatitis——
B58.1 - Toxoplasma hepatitis——
B67.0 - Echinococcus granulosus infection of liver——
B67.5 - Echinococcus multilocularis infection of liver——
B67.8 - Echinococcosis, unspecified, of liver——
B94.2 - Sequelae of viral hepatitis——
B96.81 - Helicobacter pylori [H. pylori] as the cause of diseases classified elsewhere——
C00.0 - Malignant neoplasm of external upper lip——

References