• LDS
  • /Medical Tests
  • /Hepatitis B Surface Antigen (HBsAg), Qualitative or Quantitative

Diseases (53)
Diagnostic Testing (42)

Note: Rule out hepatitis B virus infection.

Note: Rule out Hepatitis B.

Note: Rule out hepatitis B.

Note: Differential diagnosis of HBV infection.

Note: Rule out hepatitis B virus infection.

Note: R/O Hepatitis B

Note: Differential diagnosis of hepatitis B viral infection.

Note: In patients considered for rituximab therapy.

Note: Rule out hepatitis B infection.

Note: Rule out Hepatitis B caused cryoglobulinemia.

Note: Rule out hepatitis B.

Note: Rule out hepatitis B infection in patients using needles.

Note: Screening for infection with Hepatitis B virus due to dialysis.

Note: Rule out hepatitis B infection.

Note: Rule out hepatitis B infection.

Note: Rule out hepatitis B.

Note: If evidence of liver disease is present.

Note: R/O Viral hepatitis in patients with evidence of hepatocellular injury

Note: Rule out hepatitis B.

Note: Rule out hepatitis B.

Note: Rule out hepatitis B infection in patients using IV heroin.

Note: Rule out hepatitis B.

Note: Rule out Hepatitis B virus infection.

Note: Rule out vasculitis caused by hepatitis B.

Note: Rule out hepatitis B.

Note: Rule out hepatitis B infection.

Note: Rule out hepatitis B.
Other Supportive/Alternative Tests (2)

Note: If Hep B infection is indicated.

Note: Hepatitis B testing should be ordered in patients for whom rituximab is being considered.

Overview

Hepatitis B infection is caused by the Hepatitis B Virus. Hepatitis B virus is spread by contact with contaminated blood and body fluids. Chronic infection with Hepatitis B virus results in damage to the liver, cirrhosis and/or liver cancer. The body’s immune system is responsible for the liver tissue damage because it destroys the liver cells containing the virus. Consumption of alcohol during infection with Hepatitis B virus is discouraged because it can increase the damage to the liver. Hepatitis B virus is prevented by cautious and safe handling of blood and body fluids, vaccination, and refraining from behavior known to be associated with acquisition of the virus. Serology testing to detect hepatitis B surface antigen (HBsAg) is the standard for diagnosing the disease.

In hepatitis B virus infection, surface antigen is detectable 2 – 5 weeks before onset of symptoms, rises in titer, and peaks at about the time of onset of clinical illness. Generally it persists for 1 – 5 months, declining in titer and disappearing with resolution of clinical symptoms. HBsAg is a first-line test for the diagnosis of acute or chronic hepatitis B. If positive, no other test is needed. HBsAg is an indicator for active infection. It is a marker used for detecting initial infection, monitoring the course of the infection, and progression to chronic disease. It is also used in the screening of donor blood.

Clinical Utility

  • Diagnosis of HBV infection
  • Diagnosis of HBV active infection
  • Monitoring the course of the infection and progression to chronic disease
  • Blood donor screening

Interpretation

Positive in:

  • Acute hepatitis B
  • Chronic hepatitis B (persistence of HBsAg for >6 months)
  • HBsAg-positive carriers

Note: In rare cases HBsAg might be negative (when tested early). If clinical suspicion is high, HBcAb (IgM) test is then indicated.

Reference Ranges

Negative (Non-reactive)

 

Methodology
Enzyme immunoassay, Chemiluminescence immunoassay.

Specimen Collection

Serum (SST) or Plasma EDTA (Lavender) or Plasma Heparin. 

Stability

  • Ambient: 3-5 days
  • Refrigerated: 5-7 days
  • Frozen: 30 days

Additional Testing

HBsAg is definitive for diagnosing infection with Hepatitis B Virus. Other tests useful in monitoring HBV Infection: Total Anti-HBc, HBeAg, HBV DNA, Liver Function Tests, Lactate Dehydrogenase, Liver Biopsy.

CPT
87340$10.33
87341$10.33
87467$25.32

ICD10
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Showing results for all states.
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ICD10 CODE AND DESCRIPTIONLCD CODENCD CODE
A06.4 - Amebic liver abscess——
A15 - Respiratory tuberculosis——
A15.0 - Tuberculosis of lung——
A15.8 - Other respiratory tuberculosis——
A17 - Tuberculosis of nervous system——
A17.0 - Tuberculous meningitis——
A17.9 - Tuberculosis of nervous system, unspecified——
A18 - Tuberculosis of other organs——
A18.11 - Tuberculosis of kidney and ureter——
A18.31 - Tuberculous peritonitis——
A19 - Miliary tuberculosis——
A19.0 - Acute miliary tuberculosis of a single specified site——
A19.1 - Acute miliary tuberculosis of multiple sites——
A19.2 - Acute miliary tuberculosis, unspecified——
A19.8 - Other miliary tuberculosis——
A19.9 - Miliary tuberculosis, unspecified——
A31 - Infection due to other mycobacteria——
A31.0 - Pulmonary mycobacterial infection——
A41.9 - Sepsis, unspecified organism——
A49.01 - Methicillin susceptible Staphylococcus aureus infection, unspecified site——
A52.04 - Syphilitic cerebral arteritis——
A54.85 - Gonococcal peritonitis——
A69.22 - Other neurologic disorders in Lyme disease——
B00.81 - Herpesviral hepatitis——
B02.23 - Postherpetic polyneuropathy——
B02.9 - Zoster without complications——
B15 - Acute hepatitis A——
B15.0 - Hepatitis A with hepatic coma——
B15.9 - Hepatitis A without hepatic coma——
B16 - Acute hepatitis B——
B16.0 - Acute hepatitis B with delta-agent with hepatic coma——
B16.1 - Acute hepatitis B with delta-agent without hepatic coma——
B16.2 - Acute hepatitis B without delta-agent with hepatic coma——
B16.9 - Acute hepatitis B without delta-agent and without hepatic coma——
B17 - Other acute viral hepatitis——
B17.0 - Acute delta-(super) infection of hepatitis B carrier——
B17.1 - Acute hepatitis C——
B17.10 - Acute hepatitis C without hepatic coma——
B17.11 - Acute hepatitis C with hepatic coma——
B17.2 - Acute hepatitis E——
B17.8 - Other specified acute viral hepatitis——
B17.9 - Acute viral hepatitis, unspecified——
B18 - Chronic viral hepatitis——
B18.0 - Chronic viral hepatitis B with delta-agent——
B18.1 - Chronic viral hepatitis B without delta-agent——
B18.2 - Chronic viral hepatitis C——
B18.8 - Other chronic viral hepatitis——
B18.9 - Chronic viral hepatitis, unspecified——
B19 - Unspecified viral hepatitis——
B19.0 - Unspecified viral hepatitis with hepatic coma——

Additional ICD10
  • AK - Alaska
  • AL - Alabama
  • AR - Arkansas
  • AS - American Samoa
  • AZ - Arizona
  • CA - California - Entire State
  • CO - Colorado
  • CT - Connecticut
  • DC - District of Columbia
  • DE - Delaware
  • FL - Florida
  • GA - Georgia
  • GU - Guam
  • HI - Hawaii
  • IA - Iowa
  • ID - Idaho
  • IL - Illinois
  • IN - Indiana
  • KS - Kansas
  • KY - Kentucky
  • LA - Louisiana
  • MA - Massachusetts
  • MD - Maryland
  • ME - Maine
  • MI - Michigan
  • MN - Minnesota
  • MO - Missouri - Entire State
  • MS - Mississippi
  • MT - Montana
  • NC - North Carolina
  • ND - North Dakota
  • NE - Nebraska
  • NH - New Hampshire
  • NJ - New Jersey
  • NM - New Mexico
  • NV - Nevada
  • NY - New York - Entire State
  • OH - Ohio
  • OK - Oklahoma
  • OR - Oregon
  • PA - Pennsylvania
  • PR - Puerto Rico
  • RI - Rhode Island
  • SC - South Carolina
  • SD - South Dakota
  • TN - Tennessee
  • TX - Texas
  • UT - Utah
  • VA - Virginia
  • VI - Virgin Islands
  • VT - Vermont
  • WA - Washington
  • WI - Wisconsin
  • WV - West Virginia
  • WY - Wyoming
  • CNMI - Northern Mariana Islands
  • EM - Missouri - Northeastern & Southern
  • WM - Missouri - Northwestern
  • DN - New York - Downstate
  • QN - New York - Queens
  • UN - New York - Upstate
  • NF - California - Northern
  • SF - California - Southern
Showing results for all states.
Filter:
ICD10 CODE AND DESCRIPTIONLCD CODENCD CODE
A06.4 - Amebic liver abscess——
A15.0 - Tuberculosis of lung——
A15.4 - Tuberculosis of intrathoracic lymph nodes——
A15.5 - Tuberculosis of larynx, trachea and bronchus——
A15.6 - Tuberculous pleurisy——
A15.7 - Primary respiratory tuberculosis——
A15.8 - Other respiratory tuberculosis——
A15.9 - Respiratory tuberculosis unspecified——
A17.0 - Tuberculous meningitis——
A17.1 - Meningeal tuberculoma——
A17.8 - Other tuberculosis of nervous system——
A17.81 - Tuberculoma of brain and spinal cord——
A17.82 - Tuberculous meningoencephalitis——
A17.83 - Tuberculous neuritis——
A17.89 - Other tuberculosis of nervous system——
A17.9 - Tuberculosis of nervous system, unspecified——
A18.0 - Tuberculosis of bones and joints——
A18.01 - Tuberculosis of spine——
A18.02 - Tuberculous arthritis of other joints——
A18.03 - Tuberculosis of other bones——
A18.09 - Other musculoskeletal tuberculosis——
A18.1 - Tuberculosis of genitourinary system——
A18.10 - Tuberculosis of genitourinary system, unspecified——
A18.11 - Tuberculosis of kidney and ureter——
A18.12 - Tuberculosis of bladder——
A18.13 - Tuberculosis of other urinary organs——
A18.14 - Tuberculosis of prostate——
A18.15 - Tuberculosis of other male genital organs——
A18.16 - Tuberculosis of cervix——
A18.17 - Tuberculous female pelvic inflammatory disease——
A18.18 - Tuberculosis of other female genital organs——
A18.2 - Tuberculous peripheral lymphadenopathy——
A18.3 - Tuberculosis of intestines, peritoneum and mesenteric glands——
A18.31 - Tuberculous peritonitis——
A18.32 - Tuberculous enteritis——
A18.39 - Retroperitoneal tuberculosis——
A18.4 - Tuberculosis of skin and subcutaneous tissue——
A18.5 - Tuberculosis of eye——
A18.50 - Tuberculosis of eye, unspecified——
A18.51 - Tuberculous episcleritis——
A18.52 - Tuberculous keratitis——
A18.53 - Tuberculous chorioretinitis——
A18.54 - Tuberculous iridocyclitis——
A18.59 - Other tuberculosis of eye——
A18.6 - Tuberculosis of (inner) (middle) ear——
A18.7 - Tuberculosis of adrenal glands——
A18.8 - Tuberculosis of other specified organs——
A18.81 - Tuberculosis of thyroid gland——
A18.82 - Tuberculosis of other endocrine glands——
A18.83 - Tuberculosis of digestive tract organs, not elsewhere classified——

References

  • Gut. 2011 Dec 16. [PMID: 22180061]
  • Hosp Med. 2002;63:16. [PMID: 11828810]
  • Am J Gastroenterol. 2006;101(Suppl):S1. [PMID: 16448446]
  • Am J Med. 2005;118 (Suppl 10A):28S. [PMID: 16271538]
  • Clin Liver Dis. 2004;8:267. [PMID: 15481340]
  • Gastroenterol Clin Biol. 2008 Jan;32(1 Pt 2):S56-63. [PMID: 18662611]
  • N Engl J Med. 2004 Mar 11;350(11):1118-29. [PMID: 15014185]
  • Stevens, CD. Clinical Immunology & Serology A Laboratory Perspective 3rd edition. Philadelphia: F.A. Davis Company (2010).
  • Burtis C, Ashwood E, and Bruns D. Fundamentals of Clinical Chemistry. St. Louis: Saunders (2008).