Positive in:

• Patients with family history of hypercoagulability secondary to Factor V Leiden mutation
• Patients with history of recurrent miscarriages
• Venous thrombosis
• Stroke
• Pulmonary embolism
• Deep venous thrombosis
• Heart attack and stroke

Individuals who are heterozygous for the Factor V Leiden mutation have a 5- to 10-fold increased risk of venous thrombosis, while homozygous individuals have a 50 to 100-fold increased risk of venous thrombosis.