Diseases (14)
Diagnostic Testing (12)

Note:

Note:

To evaluate for resistance to anti-EGFR therapy in colorectal cancer.


Note:

To evaluate for resistance to anti-EGFR therapy in colorectal cancer.


Note:

Highly specific in papillary thyroid carcinoma.


Note:

Highly specific in papillary thyroid carcinoma.


Note:

Rule out Lynch syndrome in people who show loss of MLH1 IHC staining on colorectal tissue.


Note:

Rule out papillary thyroid carcinoma.

Overview

B-RAF is an oncogene belonging to the RAF family of serine–threonine-specific protein kinases, downstream of the epidermal growth factor receptor (EGFR) and the RAS family of small G-proteins (KRAS, HRAS, and NRAS) in the MAPK pathway. More than 30 mutations of the BRAF gene associated with human cancers have been identified. These mutations make the B-RRAF oncogene active, continuously sending signal downstream to the MAPK pathway, which then results in cell proliferation. The most common mutation is the missense mutation in codon 600 of exon 15 located on chromosome 7. BRAF mutations are most often found in melanoma (80%), colorectal cancer (5%), lung cancer (3%), ovarian cancer, and thyroid gland cancer. They are also found in lower prevalence in some other cancers such as acute myeloid leukemia, glioma, sarcomas, breast cancer, and hepatoma. More than 90% of mutations are the V600E (1799T>A) mutation. Recent studies have shown that metastatic colorectal cancer patients with this BRAF mutation do not have a strong response to anti-EGFR therapies such as cetuximab and panitumumab. This assay detects any amino acid change that has an A nucleotide at position 1799 in exon 15 of the BRAF gene regardless of any other common changes (could detect V600E/V600K/V600D), allowing identification of patients who are likely to benefit from such treatment.
The presence of somatic mutation in the B-RAF gene product, located downstream of EGFR signaling, has been shown to serve as a biomarker for poor prognosis and poor response to anti-EGFR cancer therapy in cancer patients.
Treatment of certain types of cancer with drugs targeted specifically at the EGFR receptor work only if there is no mutation of the EGFR pathway, which incldes BRAF. Therefore, before starting such therapy, analysis for EGFR family mutations is required. In fact, insurance companies do require this. Also BRAF is related to microsatellite instability status such that BRAF V600E positivity is unlikely to be a MLH1 mutant. In thyroid papillary carcinoma, BRAF mutation results in an aggressive phenotype so that knowledge of this status aids in treatment planning and recurrence risk assessment. 30 - 40% of papillary thyroid cancers are BRAF mutation positive. Treatment with MEK inhibitors may be useful in this group. About 35-45% of melanomas are BRAF muatation positive and this mutation is present in non-malignant nevi so that early detection may be possible. Melanomas with BRAF mutation are also sensitive to MEK inhibitors. 10-20% of ovarian cancers are positive for either BRAF or KRAS mutation, mostly low grade non-serous types.

Clinical Utility
  • Determining eligibility of and monitoring treatment with anti-EGFR therapy (cetuximab and panitumumab)
  • As an aid in diagnosis and management of melanoma
  • As an aid in diagnosis and management of colorectal cancer
  • As an aid in diagnosis and management of lung cancer
  • As an aid in diagnosis and management of thyroid cancer
  • Therapy monitoring and disease management

Interpretation
  • If either the BRAF V600E mutation or MLH1 promoter methylation is found in a microsatellite unstable tumor, then the tumor is probably sporadic and further work-up for HNPCC may not be warranted.
  • If no BRAF mutation or MLH1 methylation is found, then the tumor may be either sporadic or inherited, and further work-up for HNPCC is recommended. It is known now that the BRAF p.V600E mutation is detected in more than 70% tumors with loss of MLH1 due to promoter hypermethylation but is rarely detected in tumors with a germline MLH1 gene mutation. Thus, a germline mutation within the MLH1 gene is very unlikely in this case.
  • When testing is performed for therapeutic selection, especially for the efficacy of EGFR-targeted therapies in colorectal cancer, tumors lacking KRAS and BRAF might not be the best choice and may have limited therapeutic value for this patient.
  • Detection of BRF V600 mutation in melanoma might indicate good respond to BRAF targeted therapy.

    Positive :

  • Melanomas
  • Colorectal cancer
  • Lung cancer
  • Ovarian cancer
  • Thyroid gland cancer
  • Acute myeloid leukemia
  • Glioma
  • Sarcomas
  • Breast cancer
  • Hepatoma

Reference Ranges

Mutation not detected (Negative for mutation analyzed)
 

 

Methodology

Amplification refractory mutation system (ARMS), or real-time PCR detection method with single nucleotide extension, Chip array technology with allele specific primer extension, Pyrosequencing, conventional sequencing

Specimen Collection

Formalin fixed paraffin embedded (FFPE) tumor samples. Microdissection is recommended for better sensitivity and specificity. This would increase the fraction of tumor cells in the sample as it allows capture of the tumor cells. The presence of normal cells that carry wild type alleles can dilute the tumor cells, and dilution by normal and inflammatory cells might impact the sensitivity of mutation detection.

In colorectal cancer DNA can be also isolated from stool samples obtained from patients with colorectal cancer.

In lung cancer, sputum can be used for isolation of DNA from cancer cells.

Additional Testing

K-ras Gene Mutation Detection, Cytokeratin 8/18 Low Molecular Weight (CAM 5.2) by IHC (for melanoma), KIT Mutations (for melanoma), NRAS Mutation Detection (for melanoma), Microsatellite Instability/HNPCC by molecular method and by IHC (for colon cancer), Septin 9 (SEPT9) for colon cancer, Methylated DNA Detection by Real-Time PCR (for lung cancer), EGFR by FISH (for lung cancer), EGFR Mutation Detection by molecular method, p53 by molecular method and by IHC, Ki67 by IHC.

CPT
81210$ 175.4

ICD10
C18Malignant neoplasm of colon
C18.2Malignant neoplasm of ascending colon
C18.4Malignant neoplasm of transverse colon
C18.6Malignant neoplasm of descending colon
C18.7Malignant neoplasm of sigmoid colon
C18.9Malignant neoplasm of colon, unspecified
C19Malignant neoplasm of rectosigmoid junction
C20Malignant neoplasm of rectum
C21Malignant neoplasm of anus and anal canal
C21.0Malignant neoplasm of anus, unspecified
C21.1Malignant neoplasm of anal canal
C21.8Malignant neoplasm of overlapping sites of rectum, anus and anal canal
C34Malignant neoplasm of bronchus and lung
C34.0Malignant neoplasm of main bronchus
C34.10Malignant neoplasm of upper lobe, unspecified bronchus or lung
C34.11Malignant neoplasm of upper lobe, right bronchus or lung
C34.3Malignant neoplasm of lower lobe, bronchus or lung
C34.9Malignant neoplasm of unspecified part of bronchus or lung
C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
C43Malignant melanoma of skin
C43.9Malignant melanoma of skin, unspecified
C56Malignant neoplasm of ovary
C71Malignant neoplasm of brain
C71.0Malignant neoplasm of cerebrum, except lobes and ventricles
C71.1Malignant neoplasm of frontal lobe
C71.2Malignant neoplasm of temporal lobe
C71.3Malignant neoplasm of parietal lobe
C71.4Malignant neoplasm of occipital lobe
C71.5Malignant neoplasm of cerebral ventricle
C71.6Malignant neoplasm of cerebellum
C71.7Malignant neoplasm of brain stem
C71.8Malignant neoplasm of overlapping sites of brain
C71.9Malignant neoplasm of brain, unspecified
C73Malignant neoplasm of thyroid gland
C78Secondary malignant neoplasm of respiratory and digestive organs
C78.0Secondary malignant neoplasm of lung
C78.00Secondary malignant neoplasm of unspecified lung
C78.01Secondary malignant neoplasm of right lung
C78.02Secondary malignant neoplasm of left lung
C82Follicular lymphoma
C82.89Other types of follicular lymphoma, extranodal and solid organ sites
C82.90Follicular lymphoma, unspecified, unspecified site
C82.99Follicular lymphoma, unspecified, extranodal and solid organ sites
C85Other specified and unspecified types of non-Hodgkin lymphoma
C85.90Non-Hodgkin lymphoma, unspecified, unspecified site
D03Melanoma in situ
D12Benign neoplasm of colon, rectum, anus and anal canal
D22Melanocytic nevi
D22.10Melanocytic nevi of unspecified eyelid, including canthus
D22.39Melanocytic nevi of other parts of face
D22.9Melanocytic nevi, unspecified
D33Benign neoplasm of brain and other parts of central nervous system
D34Benign neoplasm of thyroid gland
D38.1Neoplasm of uncertain behavior of trachea, bronchus and lung
D3ABenign neuroendocrine tumors
D3A.8Other benign neuroendocrine tumors
D44Neoplasm of uncertain behavior of endocrine glands
D44.0Neoplasm of uncertain behavior of thyroid gland
D48Neoplasm of uncertain behavior of other and unspecified sites
D48.5Neoplasm of uncertain behavior of skin
D49Neoplasms of unspecified behavior
D49.2Neoplasm of unspecified behavior of bone, soft tissue, and skin
E31Polyglandular dysfunction
E31.2Multiple endocrine neoplasia [MEN] syndromes
E31.20Multiple endocrine neoplasia [MEN] syndrome, unspecified
R91Abnormal findings on diagnostic imaging of lung
R97Abnormal tumor markers
R97.0Elevated carcinoembryonic antigen [CEA]
Z08Encounter for follow-up examination after completed treatment for malignant neoplasm
Z80.0Family history of malignant neoplasm of digestive organs
Z80.1Family history of malignant neoplasm of trachea, bronchus and lung
Z83.71Family history of colonic polyps
Z85Personal history of malignant neoplasm
Z85.0Personal history of malignant neoplasm of digestive organs
Z85.038Personal history of other malignant neoplasm of large intestine
Z85.048Personal history of other malignant neoplasm of rectum, rectosigmoid junction, and anus
Z85.05Personal history of malignant neoplasm of liver
Z85.1Personal history of malignant neoplasm of trachea, bronchus and lung
Z85.11Personal history of malignant neoplasm of bronchus and lung
Z85.110Personal history of malignant carcinoid tumor of bronchus and lung
Z85.118Personal history of other malignant neoplasm of bronchus and lung
Z85.820Personal history of malignant melanoma of skin
Z85.850Personal history of malignant neoplasm of thyroid
Z85.9Personal history of malignant neoplasm, unspecified
Z86.004Personal history of in-situ neoplasm of other and unspecified digestive organs
Z86.010Personal history of colonic polyps
Z87.19Personal history of other diseases of the digestive system

Additional ICD10
C18.0Malignant neoplasm of cecum
C18.1Malignant neoplasm of appendix
C18.2Malignant neoplasm of ascending colon
C18.3Malignant neoplasm of hepatic flexure
C18.4Malignant neoplasm of transverse colon
C18.5Malignant neoplasm of splenic flexure
C18.6Malignant neoplasm of descending colon
C18.7Malignant neoplasm of sigmoid colon
C18.8Malignant neoplasm of overlapping sites of colon
C18.9Malignant neoplasm of colon, unspecified
C21.0Malignant neoplasm of anus, unspecified
C21.1Malignant neoplasm of anal canal
C21.2Malignant neoplasm of cloacogenic zone
C21.8Malignant neoplasm of overlapping sites of rectum, anus and anal canal
C34.0Malignant neoplasm of main bronchus
C34.00Malignant neoplasm of unspecified main bronchus
C34.01Malignant neoplasm of right main bronchus
C34.02Malignant neoplasm of left main bronchus
C34.1Malignant neoplasm of upper lobe, bronchus or lung
C34.10Malignant neoplasm of upper lobe, unspecified bronchus or lung
C34.11Malignant neoplasm of upper lobe, right bronchus or lung
C34.12Malignant neoplasm of upper lobe, left bronchus or lung
C34.2Malignant neoplasm of middle lobe, bronchus or lung
C34.3Malignant neoplasm of lower lobe, bronchus or lung
C34.30Malignant neoplasm of lower lobe, unspecified bronchus or lung
C34.31Malignant neoplasm of lower lobe, right bronchus or lung
C34.32Malignant neoplasm of lower lobe, left bronchus or lung
C34.8Malignant neoplasm of overlapping sites of bronchus and lung
C34.80Malignant neoplasm of overlapping sites of unspecified bronchus and lung
C34.81Malignant neoplasm of overlapping sites of right bronchus and lung
C34.82Malignant neoplasm of overlapping sites of left bronchus and lung
C34.9Malignant neoplasm of unspecified part of bronchus or lung
C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
C34.91Malignant neoplasm of unspecified part of right bronchus or lung
C34.92Malignant neoplasm of unspecified part of left bronchus or lung
C43.0Malignant melanoma of lip
C43.1Malignant melanoma of eyelid, including canthus
C43.10Malignant melanoma of unspecified eyelid, including canthus
C43.11Malignant melanoma of right eyelid, including canthus
C43.111Malignant melanoma of right upper eyelid, including canthus
C43.112Malignant melanoma of right lower eyelid, including canthus
C43.12Malignant melanoma of left eyelid, including canthus
C43.121Malignant melanoma of left upper eyelid, including canthus
C43.122Malignant melanoma of left lower eyelid, including canthus
C43.2Malignant melanoma of ear and external auricular canal
C43.20Malignant melanoma of unspecified ear and external auricular canal
C43.21Malignant melanoma of right ear and external auricular canal
C43.22Malignant melanoma of left ear and external auricular canal
C43.3Malignant melanoma of other and unspecified parts of face
C43.30Malignant melanoma of unspecified part of face
C43.31Malignant melanoma of nose
C43.39Malignant melanoma of other parts of face
C43.4Malignant melanoma of scalp and neck
C43.5Malignant melanoma of trunk
C43.51Malignant melanoma of anal skin
C43.52Malignant melanoma of skin of breast
C43.59Malignant melanoma of other part of trunk
C43.6Malignant melanoma of upper limb, including shoulder
C43.60Malignant melanoma of unspecified upper limb, including shoulder
C43.61Malignant melanoma of right upper limb, including shoulder
C43.62Malignant melanoma of left upper limb, including shoulder
C43.7Malignant melanoma of lower limb, including hip
C43.70Malignant melanoma of unspecified lower limb, including hip
C43.71Malignant melanoma of right lower limb, including hip
C43.72Malignant melanoma of left lower limb, including hip
C43.8Malignant melanoma of overlapping sites of skin
C43.9Malignant melanoma of skin, unspecified
C56.1Malignant neoplasm of right ovary
C56.2Malignant neoplasm of left ovary
C56.9Malignant neoplasm of unspecified ovary
C71.0Malignant neoplasm of cerebrum, except lobes and ventricles
C71.1Malignant neoplasm of frontal lobe
C71.2Malignant neoplasm of temporal lobe
C71.3Malignant neoplasm of parietal lobe
C71.4Malignant neoplasm of occipital lobe
C71.5Malignant neoplasm of cerebral ventricle
C71.6Malignant neoplasm of cerebellum
C71.7Malignant neoplasm of brain stem
C71.8Malignant neoplasm of overlapping sites of brain
C71.9Malignant neoplasm of brain, unspecified
C75.0Malignant neoplasm of parathyroid gland
C78.0Secondary malignant neoplasm of lung
C78.00Secondary malignant neoplasm of unspecified lung
C78.01Secondary malignant neoplasm of right lung
C78.02Secondary malignant neoplasm of left lung
C78.1Secondary malignant neoplasm of mediastinum
C78.2Secondary malignant neoplasm of pleura
C78.3Secondary malignant neoplasm of other and unspecified respiratory organs
C78.30Secondary malignant neoplasm of unspecified respiratory organ
C78.39Secondary malignant neoplasm of other respiratory organs
C78.4Secondary malignant neoplasm of small intestine
C78.5Secondary malignant neoplasm of large intestine and rectum
C78.6Secondary malignant neoplasm of retroperitoneum and peritoneum
C78.7Secondary malignant neoplasm of liver and intrahepatic bile duct
C78.8Secondary malignant neoplasm of other and unspecified digestive organs
C78.80Secondary malignant neoplasm of unspecified digestive organ
C78.89Secondary malignant neoplasm of other digestive organs
C7A.022Malignant carcinoid tumor of the ascending colon
C7A.023Malignant carcinoid tumor of the transverse colon
C7A.024Malignant carcinoid tumor of the descending colon
C7A.025Malignant carcinoid tumor of the sigmoid colon
C82.0Follicular lymphoma grade I
C82.00Follicular lymphoma grade I, unspecified site
C82.01Follicular lymphoma grade I, lymph nodes of head, face, and neck
C82.02Follicular lymphoma grade I, intrathoracic lymph nodes
C82.03Follicular lymphoma grade I, intra-abdominal lymph nodes
C82.04Follicular lymphoma grade I, lymph nodes of axilla and upper limb
C82.05Follicular lymphoma grade I, lymph nodes of inguinal region and lower limb
C82.06Follicular lymphoma grade I, intrapelvic lymph nodes
C82.07Follicular lymphoma grade I, spleen
C82.08Follicular lymphoma grade I, lymph nodes of multiple sites
C82.09Follicular lymphoma grade I, extranodal and solid organ sites
C82.1Follicular lymphoma grade II
C82.10Follicular lymphoma grade II, unspecified site
C82.11Follicular lymphoma grade II, lymph nodes of head, face, and neck
C82.12Follicular lymphoma grade II, intrathoracic lymph nodes
C82.13Follicular lymphoma grade II, intra-abdominal lymph nodes
C82.14Follicular lymphoma grade II, lymph nodes of axilla and upper limb
C82.15Follicular lymphoma grade II, lymph nodes of inguinal region and lower limb
C82.16Follicular lymphoma grade II, intrapelvic lymph nodes
C82.17Follicular lymphoma grade II, spleen
C82.18Follicular lymphoma grade II, lymph nodes of multiple sites
C82.19Follicular lymphoma grade II, extranodal and solid organ sites
C82.2Follicular lymphoma grade III, unspecified
C82.20Follicular lymphoma grade III, unspecified, unspecified site
C82.21Follicular lymphoma grade III, unspecified, lymph nodes of head, face, and neck
C82.22Follicular lymphoma grade III, unspecified, intrathoracic lymph nodes
C82.23Follicular lymphoma grade III, unspecified, intra-abdominal lymph nodes
C82.24Follicular lymphoma grade III, unspecified, lymph nodes of axilla and upper limb
C82.25Follicular lymphoma grade III, unspecified, lymph nodes of inguinal region and lower limb
C82.26Follicular lymphoma grade III, unspecified, intrapelvic lymph nodes
C82.27Follicular lymphoma grade III, unspecified, spleen
C82.28Follicular lymphoma grade III, unspecified, lymph nodes of multiple sites
C82.29Follicular lymphoma grade III, unspecified, extranodal and solid organ sites
C82.3Follicular lymphoma grade IIIa
C82.30Follicular lymphoma grade IIIa, unspecified site
C82.31Follicular lymphoma grade IIIa, lymph nodes of head, face, and neck
C82.32Follicular lymphoma grade IIIa, intrathoracic lymph nodes
C82.33Follicular lymphoma grade IIIa, intra-abdominal lymph nodes
C82.34Follicular lymphoma grade IIIa, lymph nodes of axilla and upper limb
C82.35Follicular lymphoma grade IIIa, lymph nodes of inguinal region and lower limb
C82.36Follicular lymphoma grade IIIa, intrapelvic lymph nodes
C82.37Follicular lymphoma grade IIIa, spleen
C82.38Follicular lymphoma grade IIIa, lymph nodes of multiple sites
C82.39Follicular lymphoma grade IIIa, extranodal and solid organ sites
C82.4Follicular lymphoma grade IIIb
C82.40Follicular lymphoma grade IIIb, unspecified site
C82.41Follicular lymphoma grade IIIb, lymph nodes of head, face, and neck
C82.42Follicular lymphoma grade IIIb, intrathoracic lymph nodes
C82.43Follicular lymphoma grade IIIb, intra-abdominal lymph nodes
C82.44Follicular lymphoma grade IIIb, lymph nodes of axilla and upper limb
C82.45Follicular lymphoma grade IIIb, lymph nodes of inguinal region and lower limb
C82.46Follicular lymphoma grade IIIb, intrapelvic lymph nodes
C82.47Follicular lymphoma grade IIIb, spleen
C82.48Follicular lymphoma grade IIIb, lymph nodes of multiple sites
C82.49Follicular lymphoma grade IIIb, extranodal and solid organ sites
C82.5Diffuse follicle center lymphoma
C82.50Diffuse follicle center lymphoma, unspecified site
C82.51Diffuse follicle center lymphoma, lymph nodes of head, face, and neck
C82.52Diffuse follicle center lymphoma, intrathoracic lymph nodes
C82.53Diffuse follicle center lymphoma, intra-abdominal lymph nodes
C82.54Diffuse follicle center lymphoma, lymph nodes of axilla and upper limb
C82.55Diffuse follicle center lymphoma, lymph nodes of inguinal region and lower limb
C82.56Diffuse follicle center lymphoma, intrapelvic lymph nodes
C82.57Diffuse follicle center lymphoma, spleen
C82.58Diffuse follicle center lymphoma, lymph nodes of multiple sites
C82.59Diffuse follicle center lymphoma, extranodal and solid organ sites
C82.6Cutaneous follicle center lymphoma
C82.60Cutaneous follicle center lymphoma, unspecified site
C82.61Cutaneous follicle center lymphoma, lymph nodes of head, face, and neck
C82.62Cutaneous follicle center lymphoma, intrathoracic lymph nodes
C82.63Cutaneous follicle center lymphoma, intra-abdominal lymph nodes
C82.64Cutaneous follicle center lymphoma, lymph nodes of axilla and upper limb
C82.65Cutaneous follicle center lymphoma, lymph nodes of inguinal region and lower limb
C82.66Cutaneous follicle center lymphoma, intrapelvic lymph nodes
C82.67Cutaneous follicle center lymphoma, spleen
C82.68Cutaneous follicle center lymphoma, lymph nodes of multiple sites
C82.69Cutaneous follicle center lymphoma, extranodal and solid organ sites
C82.8Other types of follicular lymphoma
C82.80Other types of follicular lymphoma, unspecified site
C82.81Other types of follicular lymphoma, lymph nodes of head, face, and neck
C82.82Other types of follicular lymphoma, intrathoracic lymph nodes
C82.83Other types of follicular lymphoma, intra-abdominal lymph nodes
C82.84Other types of follicular lymphoma, lymph nodes of axilla and upper limb
C82.85Other types of follicular lymphoma, lymph nodes of inguinal region and lower limb
C82.86Other types of follicular lymphoma, intrapelvic lymph nodes
C82.87Other types of follicular lymphoma, spleen
C82.88Other types of follicular lymphoma, lymph nodes of multiple sites
C82.89Other types of follicular lymphoma, extranodal and solid organ sites
C82.9Follicular lymphoma, unspecified
C82.90Follicular lymphoma, unspecified, unspecified site
C82.91Follicular lymphoma, unspecified, lymph nodes of head, face, and neck
C82.92Follicular lymphoma, unspecified, intrathoracic lymph nodes
C82.93Follicular lymphoma, unspecified, intra-abdominal lymph nodes
C82.94Follicular lymphoma, unspecified, lymph nodes of axilla and upper limb
C82.95Follicular lymphoma, unspecified, lymph nodes of inguinal region and lower limb
C82.96Follicular lymphoma, unspecified, intrapelvic lymph nodes
C82.97Follicular lymphoma, unspecified, spleen
C82.98Follicular lymphoma, unspecified, lymph nodes of multiple sites
C82.99Follicular lymphoma, unspecified, extranodal and solid organ sites
C85.1Unspecified B-cell lymphoma
C85.10Unspecified B-cell lymphoma, unspecified site
C85.11Unspecified B-cell lymphoma, lymph nodes of head, face, and neck
C85.12Unspecified B-cell lymphoma, intrathoracic lymph nodes
C85.13Unspecified B-cell lymphoma, intra-abdominal lymph nodes
C85.14Unspecified B-cell lymphoma, lymph nodes of axilla and upper limb
C85.15Unspecified B-cell lymphoma, lymph nodes of inguinal region and lower limb
C85.16Unspecified B-cell lymphoma, intrapelvic lymph nodes
C85.17Unspecified B-cell lymphoma, spleen
C85.18Unspecified B-cell lymphoma, lymph nodes of multiple sites
C85.19Unspecified B-cell lymphoma, extranodal and solid organ sites
C85.2Mediastinal (thymic) large B-cell lymphoma
C85.20Mediastinal (thymic) large B-cell lymphoma, unspecified site
C85.21Mediastinal (thymic) large B-cell lymphoma, lymph nodes of head, face, and neck
C85.22Mediastinal (thymic) large B-cell lymphoma, intrathoracic lymph nodes
C85.23Mediastinal (thymic) large B-cell lymphoma, intra-abdominal lymph nodes
C85.24Mediastinal (thymic) large B-cell lymphoma, lymph nodes of axilla and upper limb
C85.25Mediastinal (thymic) large B-cell lymphoma, lymph nodes of inguinal region and lower limb
C85.26Mediastinal (thymic) large B-cell lymphoma, intrapelvic lymph nodes
C85.27Mediastinal (thymic) large B-cell lymphoma, spleen
C85.28Mediastinal (thymic) large B-cell lymphoma, lymph nodes of multiple sites
C85.29Mediastinal (thymic) large B-cell lymphoma, extranodal and solid organ sites
C85.8Other specified types of non-Hodgkin lymphoma
C85.80Other specified types of non-Hodgkin lymphoma, unspecified site
C85.81Other specified types of non-Hodgkin lymphoma, lymph nodes of head, face, and neck
C85.82Other specified types of non-Hodgkin lymphoma, intrathoracic lymph nodes
C85.83Other specified types of non-Hodgkin lymphoma, intra-abdominal lymph nodes
C85.84Other specified types of non-Hodgkin lymphoma, lymph nodes of axilla and upper limb
C85.85Other specified types of non-Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
C85.86Other specified types of non-Hodgkin lymphoma, intrapelvic lymph nodes
C85.87Other specified types of non-Hodgkin lymphoma, spleen
C85.88Other specified types of non-Hodgkin lymphoma, lymph nodes of multiple sites
C85.89Other specified types of non-Hodgkin lymphoma, extranodal and solid organ sites
C85.9Non-Hodgkin lymphoma, unspecified
C85.90Non-Hodgkin lymphoma, unspecified, unspecified site
C85.91Non-Hodgkin lymphoma, unspecified, lymph nodes of head, face, and neck
C85.92Non-Hodgkin lymphoma, unspecified, intrathoracic lymph nodes
C85.93Non-Hodgkin lymphoma, unspecified, intra-abdominal lymph nodes
C85.94Non-Hodgkin lymphoma, unspecified, lymph nodes of axilla and upper limb
C85.95Non-Hodgkin lymphoma, unspecified, lymph nodes of inguinal region and lower limb
C85.96Non-Hodgkin lymphoma, unspecified, intrapelvic lymph nodes
C85.97Non-Hodgkin lymphoma, unspecified, spleen
C85.98Non-Hodgkin lymphoma, unspecified, lymph nodes of multiple sites
C85.99Non-Hodgkin lymphoma, unspecified, extranodal and solid organ sites
D01.0Carcinoma in situ of colon
D03.0Melanoma in situ of lip
D03.1Melanoma in situ of eyelid, including canthus
D03.10Melanoma in situ of unspecified eyelid, including canthus
D03.11Melanoma in situ of right eyelid, including canthus
D03.111Melanoma in situ of right upper eyelid, including canthus
D03.112Melanoma in situ of right lower eyelid, including canthus
D03.12Melanoma in situ of left eyelid, including canthus
D03.121Melanoma in situ of left upper eyelid, including canthus
D03.122Melanoma in situ of left lower eyelid, including canthus
D03.2Melanoma in situ of ear and external auricular canal
D03.20Melanoma in situ of unspecified ear and external auricular canal
D03.21Melanoma in situ of right ear and external auricular canal
D03.22Melanoma in situ of left ear and external auricular canal
D03.3Melanoma in situ of other and unspecified parts of face
D03.30Melanoma in situ of unspecified part of face
D03.39Melanoma in situ of other parts of face
D03.4Melanoma in situ of scalp and neck
D03.5Melanoma in situ of trunk
D03.51Melanoma in situ of anal skin
D03.52Melanoma in situ of breast (skin) (soft tissue)
D03.59Melanoma in situ of other part of trunk
D03.6Melanoma in situ of upper limb, including shoulder
D03.60Melanoma in situ of unspecified upper limb, including shoulder
D03.61Melanoma in situ of right upper limb, including shoulder
D03.62Melanoma in situ of left upper limb, including shoulder
D03.7Melanoma in situ of lower limb, including hip
D03.70Melanoma in situ of unspecified lower limb, including hip
D03.71Melanoma in situ of right lower limb, including hip
D03.72Melanoma in situ of left lower limb, including hip
D03.8Melanoma in situ of other sites
D03.9Melanoma in situ, unspecified
D12.0Benign neoplasm of cecum
D12.1Benign neoplasm of appendix
D12.2Benign neoplasm of ascending colon
D12.3Benign neoplasm of transverse colon
D12.4Benign neoplasm of descending colon
D12.5Benign neoplasm of sigmoid colon
D12.6Benign neoplasm of colon, unspecified
D12.7Benign neoplasm of rectosigmoid junction
D12.8Benign neoplasm of rectum
D12.9Benign neoplasm of anus and anal canal
D22.0Melanocytic nevi of lip
D22.1Melanocytic nevi of eyelid, including canthus
D22.10Melanocytic nevi of unspecified eyelid, including canthus
D22.11Melanocytic nevi of right eyelid, including canthus
D22.111Melanocytic nevi of right upper eyelid, including canthus
D22.112Melanocytic nevi of right lower eyelid, including canthus
D22.12Melanocytic nevi of left eyelid, including canthus
D22.121Melanocytic nevi of left upper eyelid, including canthus
D22.122Melanocytic nevi of left lower eyelid, including canthus
D22.2Melanocytic nevi of ear and external auricular canal
D22.20Melanocytic nevi of unspecified ear and external auricular canal
D22.21Melanocytic nevi of right ear and external auricular canal
D22.22Melanocytic nevi of left ear and external auricular canal
D22.3Melanocytic nevi of other and unspecified parts of face
D22.30Melanocytic nevi of unspecified part of face
D22.39Melanocytic nevi of other parts of face
D22.4Melanocytic nevi of scalp and neck
D22.5Melanocytic nevi of trunk
D22.6Melanocytic nevi of upper limb, including shoulder
D22.60Melanocytic nevi of unspecified upper limb, including shoulder
D22.61Melanocytic nevi of right upper limb, including shoulder
D22.62Melanocytic nevi of left upper limb, including shoulder
D22.7Melanocytic nevi of lower limb, including hip
D22.70Melanocytic nevi of unspecified lower limb, including hip
D22.71Melanocytic nevi of right lower limb, including hip
D22.72Melanocytic nevi of left lower limb, including hip
D22.9Melanocytic nevi, unspecified
D33.0Benign neoplasm of brain, supratentorial
D33.1Benign neoplasm of brain, infratentorial
D33.2Benign neoplasm of brain, unspecified
D33.3Benign neoplasm of cranial nerves
D33.4Benign neoplasm of spinal cord
D33.7Benign neoplasm of other specified parts of central nervous system
D33.9Benign neoplasm of central nervous system, unspecified
D35.1Benign neoplasm of parathyroid gland
D37.4Neoplasm of uncertain behavior of colon
D3A.0Benign carcinoid tumors
D3A.00Benign carcinoid tumor of unspecified site
D3A.01Benign carcinoid tumors of the small intestine
D3A.010Benign carcinoid tumor of the duodenum
D3A.011Benign carcinoid tumor of the jejunum
D3A.012Benign carcinoid tumor of the ileum
D3A.019Benign carcinoid tumor of the small intestine, unspecified portion
D3A.02Benign carcinoid tumors of the appendix, large intestine, and rectum
D3A.020Benign carcinoid tumor of the appendix
D3A.021Benign carcinoid tumor of the cecum
D3A.022Benign carcinoid tumor of the ascending colon
D3A.023Benign carcinoid tumor of the transverse colon
D3A.024Benign carcinoid tumor of the descending colon
D3A.025Benign carcinoid tumor of the sigmoid colon
D3A.026Benign carcinoid tumor of the rectum
D3A.029Benign carcinoid tumor of the large intestine, unspecified portion
D3A.09Benign carcinoid tumors of other sites
D3A.090Benign carcinoid tumor of the bronchus and lung
D3A.091Benign carcinoid tumor of the thymus
D3A.092Benign carcinoid tumor of the stomach
D3A.093Benign carcinoid tumor of the kidney
D3A.094Benign carcinoid tumor of the foregut, unspecified
D3A.095Benign carcinoid tumor of the midgut, unspecified
D3A.096Benign carcinoid tumor of the hindgut, unspecified
D3A.098Benign carcinoid tumors of other sites
D3A.8Other benign neuroendocrine tumors
D44.0Neoplasm of uncertain behavior of thyroid gland
D44.2Neoplasm of uncertain behavior of parathyroid gland
D48.0Neoplasm of uncertain behavior of bone and articular cartilage
D48.1Neoplasm of uncertain behavior of connective and other soft tissue
D48.2Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system
D48.3Neoplasm of uncertain behavior of retroperitoneum
D48.4Neoplasm of uncertain behavior of peritoneum
D48.5Neoplasm of uncertain behavior of skin
D48.6Neoplasm of uncertain behavior of breast
D48.60Neoplasm of uncertain behavior of unspecified breast
D48.61Neoplasm of uncertain behavior of right breast
D48.62Neoplasm of uncertain behavior of left breast
D48.7Neoplasm of uncertain behavior of other specified sites
D48.9Neoplasm of uncertain behavior, unspecified
D49.0Neoplasm of unspecified behavior of digestive system
D49.1Neoplasm of unspecified behavior of respiratory system
D49.2Neoplasm of unspecified behavior of bone, soft tissue, and skin
D49.3Neoplasm of unspecified behavior of breast
D49.4Neoplasm of unspecified behavior of bladder
D49.5Neoplasm of unspecified behavior of other genitourinary organs
D49.51Neoplasm of unspecified behavior of kidney
D49.511Neoplasm of unspecified behavior of right kidney
D49.512Neoplasm of unspecified behavior of left kidney
D49.519Neoplasm of unspecified behavior of unspecified kidney
D49.59Neoplasm of unspecified behavior of other genitourinary organ
D49.6Neoplasm of unspecified behavior of brain
D49.7Neoplasm of unspecified behavior of endocrine glands and other parts of nervous system
D49.8Neoplasm of unspecified behavior of other specified sites
D49.81Neoplasm of unspecified behavior of retina and choroid
D49.89Neoplasm of unspecified behavior of other specified sites
D49.9Neoplasm of unspecified behavior of unspecified site
E31.0Autoimmune polyglandular failure
E31.1Polyglandular hyperfunction
E31.2Multiple endocrine neoplasia [MEN] syndromes
E31.20Multiple endocrine neoplasia [MEN] syndrome, unspecified
E31.21Multiple endocrine neoplasia [MEN] type I
E31.22Multiple endocrine neoplasia [MEN] type IIA
E31.23Multiple endocrine neoplasia [MEN] type IIB
E31.8Other polyglandular dysfunction
E31.9Polyglandular dysfunction, unspecified
K63.5Polyp of colon
R91.1Solitary pulmonary nodule
R91.8Other nonspecific abnormal finding of lung field
Z12.11Encounter for screening for malignant neoplasm of colon
Z83.71Family history of colonic polyps
Z85.0Personal history of malignant neoplasm of digestive organs
Z85.00Personal history of malignant neoplasm of unspecified digestive organ
Z85.01Personal history of malignant neoplasm of esophagus
Z85.02Personal history of malignant neoplasm of stomach
Z85.020Personal history of malignant carcinoid tumor of stomach
Z85.028Personal history of other malignant neoplasm of stomach
Z85.03Personal history of malignant neoplasm of large intestine
Z85.030Personal history of malignant carcinoid tumor of large intestine
Z85.038Personal history of other malignant neoplasm of large intestine
Z85.04Personal history of malignant neoplasm of rectum, rectosigmoid junction, and anus
Z85.040Personal history of malignant carcinoid tumor of rectum
Z85.048Personal history of other malignant neoplasm of rectum, rectosigmoid junction, and anus
Z85.05Personal history of malignant neoplasm of liver
Z85.06Personal history of malignant neoplasm of small intestine
Z85.060Personal history of malignant carcinoid tumor of small intestine
Z85.068Personal history of other malignant neoplasm of small intestine
Z85.07Personal history of malignant neoplasm of pancreas
Z85.09Personal history of malignant neoplasm of other digestive organs
Z85.1Personal history of malignant neoplasm of trachea, bronchus and lung
Z85.11Personal history of malignant neoplasm of bronchus and lung
Z85.110Personal history of malignant carcinoid tumor of bronchus and lung
Z85.118Personal history of other malignant neoplasm of bronchus and lung
Z85.12Personal history of malignant neoplasm of trachea
Z85.2Personal history of malignant neoplasm of other respiratory and intrathoracic organs
Z85.20Personal history of malignant neoplasm of unspecified respiratory organ
Z85.21Personal history of malignant neoplasm of larynx
Z85.22Personal history of malignant neoplasm of nasal cavities, middle ear, and accessory sinuses
Z85.23Personal history of malignant neoplasm of thymus
Z85.230Personal history of malignant carcinoid tumor of thymus
Z85.238Personal history of other malignant neoplasm of thymus
Z85.29Personal history of malignant neoplasm of other respiratory and intrathoracic organs
Z85.3Personal history of malignant neoplasm of breast
Z85.4Personal history of malignant neoplasm of genital organs
Z85.40Personal history of malignant neoplasm of unspecified female genital organ
Z85.41Personal history of malignant neoplasm of cervix uteri
Z85.42Personal history of malignant neoplasm of other parts of uterus
Z85.43Personal history of malignant neoplasm of ovary
Z85.44Personal history of malignant neoplasm of other female genital organs
Z85.45Personal history of malignant neoplasm of unspecified male genital organ
Z85.46Personal history of malignant neoplasm of prostate
Z85.47Personal history of malignant neoplasm of testis
Z85.48Personal history of malignant neoplasm of epididymis
Z85.49Personal history of malignant neoplasm of other male genital organs
Z85.5Personal history of malignant neoplasm of urinary tract
Z85.50Personal history of malignant neoplasm of unspecified urinary tract organ
Z85.51Personal history of malignant neoplasm of bladder
Z85.52Personal history of malignant neoplasm of kidney
Z85.520Personal history of malignant carcinoid tumor of kidney
Z85.528Personal history of other malignant neoplasm of kidney
Z85.53Personal history of malignant neoplasm of renal pelvis
Z85.54Personal history of malignant neoplasm of ureter
Z85.59Personal history of malignant neoplasm of other urinary tract organ
Z85.6Personal history of leukemia
Z85.7Personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues
Z85.71Personal history of Hodgkin lymphoma
Z85.72Personal history of non-Hodgkin lymphomas
Z85.79Personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues
Z85.8Personal history of malignant neoplasms of other organs and systems
Z85.81Personal history of malignant neoplasm of lip, oral cavity, and pharynx
Z85.810Personal history of malignant neoplasm of tongue
Z85.818Personal history of malignant neoplasm of other sites of lip, oral cavity, and pharynx
Z85.819Personal history of malignant neoplasm of unspecified site of lip, oral cavity, and pharynx
Z85.82Personal history of malignant neoplasm of skin
Z85.820Personal history of malignant melanoma of skin
Z85.821Personal history of Merkel cell carcinoma
Z85.828Personal history of other malignant neoplasm of skin
Z85.83Personal history of malignant neoplasm of bone and soft tissue
Z85.830Personal history of malignant neoplasm of bone
Z85.831Personal history of malignant neoplasm of soft tissue
Z85.84Personal history of malignant neoplasm of eye and nervous tissue
Z85.840Personal history of malignant neoplasm of eye
Z85.841Personal history of malignant neoplasm of brain
Z85.848Personal history of malignant neoplasm of other parts of nervous tissue
Z85.85Personal history of malignant neoplasm of endocrine glands
Z85.850Personal history of malignant neoplasm of thyroid
Z85.858Personal history of malignant neoplasm of other endocrine glands
Z85.89Personal history of malignant neoplasm of other organs and systems
Z85.9Personal history of malignant neoplasm, unspecified
Z86.010Personal history of colonic polyps
Z86.011Personal history of benign neoplasm of the brain

References