B-RAF is an oncogene belonging to the RAF family of serine–threonine-specific protein kinases, downstream of the epidermal growth factor receptor (EGFR) and the RAS family of small G-proteins (KRAS, HRAS, and NRAS) in the MAPK pathway. More than 30 mutations of the BRAF gene associated with human cancers have been identified. These mutations make the B-RRAF oncogene active, continuously sending signal downstream to the MAPK pathway, which then results in cell proliferation. The most common mutation is the missense mutation in codon 600 of exon 15 located on chromosome 7. BRAF mutations are most often found in melanoma (80%), colorectal cancer (5%), lung cancer (3%), ovarian cancer, and thyroid gland cancer. They are also found in lower prevalence in some other cancers such as acute myeloid leukemia, glioma, sarcomas, breast cancer, and hepatoma. More than 90% of mutations are the V600E (1799T>A) mutation. Recent studies have shown that metastatic colorectal cancer patients with this BRAF mutation do not have a strong response to anti-EGFR therapies such as cetuximab and panitumumab. This assay detects any amino acid change that has an A nucleotide at position 1799 in exon 15 of the BRAF gene regardless of any other common changes (could detect V600E/V600K/V600D), allowing identification of patients who are likely to benefit from such treatment.
The presence of somatic mutation in the B-RAF gene product, located downstream of EGFR signaling, has been shown to serve as a biomarker for poor prognosis and poor response to anti-EGFR cancer therapy in cancer patients.
Treatment of certain types of cancer with drugs targeted specifically at the EGFR receptor work only if there is no mutation of the EGFR pathway, which incldes BRAF. Therefore, before starting such therapy, analysis for EGFR family mutations is required. In fact, insurance companies do require this. Also BRAF is related to microsatellite instability status such that BRAF V600E positivity is unlikely to be a MLH1 mutant. In thyroid papillary carcinoma, BRAF mutation results in an aggressive phenotype so that knowledge of this status aids in treatment planning and recurrence risk assessment. 30 - 40% of papillary thyroid cancers are BRAF mutation positive. Treatment with MEK inhibitors may be useful in this group. About 35-45% of melanomas are BRAF muatation positive and this mutation is present in non-malignant nevi so that early detection may be possible. Melanomas with BRAF mutation are also sensitive to MEK inhibitors. 10-20% of ovarian cancers are positive for either BRAF or KRAS mutation, mostly low grade non-serous types.
Mutation not detected (Negative for mutation analyzed)
Amplification refractory mutation system (ARMS), or real-time PCR detection method with single nucleotide extension, Chip array technology with allele specific primer extension, Pyrosequencing, conventional sequencing
Formalin fixed paraffin embedded (FFPE) tumor samples. Microdissection is recommended for better sensitivity and specificity. This would increase the fraction of tumor cells in the sample as it allows capture of the tumor cells. The presence of normal cells that carry wild type alleles can dilute the tumor cells, and dilution by normal and inflammatory cells might impact the sensitivity of mutation detection.
In colorectal cancer DNA can be also isolated from stool samples obtained from patients with colorectal cancer.
In lung cancer, sputum can be used for isolation of DNA from cancer cells.
K-ras Gene Mutation Detection, Cytokeratin 8/18 Low Molecular Weight (CAM 5.2) by IHC (for melanoma), KIT Mutations (for melanoma), NRAS Mutation Detection (for melanoma), Microsatellite Instability/HNPCC by molecular method and by IHC (for colon cancer), Septin 9 (SEPT9) for colon cancer, Methylated DNA Detection by Real-Time PCR (for lung cancer), EGFR by FISH (for lung cancer), EGFR Mutation Detection by molecular method, p53 by molecular method and by IHC, Ki67 by IHC.
7-14 days
81210 | $ 175.4 |
C18 | Malignant neoplasm of colon |
C18.2 | Malignant neoplasm of ascending colon |
C18.4 | Malignant neoplasm of transverse colon |
C18.6 | Malignant neoplasm of descending colon |
C18.7 | Malignant neoplasm of sigmoid colon |
C18.9 | Malignant neoplasm of colon, unspecified |
C19 | Malignant neoplasm of rectosigmoid junction |
C20 | Malignant neoplasm of rectum |
C21 | Malignant neoplasm of anus and anal canal |
C21.0 | Malignant neoplasm of anus, unspecified |
C21.1 | Malignant neoplasm of anal canal |
C21.8 | Malignant neoplasm of overlapping sites of rectum, anus and anal canal |
C34 | Malignant neoplasm of bronchus and lung |
C34.0 | Malignant neoplasm of main bronchus |
C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
C43 | Malignant melanoma of skin |
C43.9 | Malignant melanoma of skin, unspecified |
C71 | Malignant neoplasm of brain |
C71.0 | Malignant neoplasm of cerebrum, except lobes and ventricles |
C71.1 | Malignant neoplasm of frontal lobe |
C71.2 | Malignant neoplasm of temporal lobe |
C71.3 | Malignant neoplasm of parietal lobe |
C71.4 | Malignant neoplasm of occipital lobe |
C71.5 | Malignant neoplasm of cerebral ventricle |
C71.6 | Malignant neoplasm of cerebellum |
C71.7 | Malignant neoplasm of brain stem |
C71.8 | Malignant neoplasm of overlapping sites of brain |
C71.9 | Malignant neoplasm of brain, unspecified |
C73 | Malignant neoplasm of thyroid gland |
C78 | Secondary malignant neoplasm of respiratory and digestive organs |
C78.0 | Secondary malignant neoplasm of lung |
C78.00 | Secondary malignant neoplasm of unspecified lung |
C78.01 | Secondary malignant neoplasm of right lung |
C78.02 | Secondary malignant neoplasm of left lung |
C82 | Follicular lymphoma |
C82.89 | Other types of follicular lymphoma, extranodal and solid organ sites |
C82.90 | Follicular lymphoma, unspecified, unspecified site |
C82.99 | Follicular lymphoma, unspecified, extranodal and solid organ sites |
C85 | Other specified and unspecified types of non-Hodgkin lymphoma |
C85.90 | Non-Hodgkin lymphoma, unspecified, unspecified site |
D03 | Melanoma in situ |
D12 | Benign neoplasm of colon, rectum, anus and anal canal |
D22 | Melanocytic nevi |
D22.10 | Melanocytic nevi of unspecified eyelid, including canthus |
D22.39 | Melanocytic nevi of other parts of face |
D22.9 | Melanocytic nevi, unspecified |
D33 | Benign neoplasm of brain and other parts of central nervous system |
D34 | Benign neoplasm of thyroid gland |
D38.1 | Neoplasm of uncertain behavior of trachea, bronchus and lung |
D3A | Benign neuroendocrine tumors |
D3A.8 | Other benign neuroendocrine tumors |
D44 | Neoplasm of uncertain behavior of endocrine glands |
D44.0 | Neoplasm of uncertain behavior of thyroid gland |
D48 | Neoplasm of uncertain behavior of other and unspecified sites |
D48.5 | Neoplasm of uncertain behavior of skin |
D49 | Neoplasms of unspecified behavior |
D49.2 | Neoplasm of unspecified behavior of bone, soft tissue, and skin |
E31 | Polyglandular dysfunction |
E31.2 | Multiple endocrine neoplasia [MEN] syndromes |
E31.20 | Multiple endocrine neoplasia [MEN] syndrome, unspecified |
R91 | Abnormal findings on diagnostic imaging of lung |
R97 | Abnormal tumor markers |
R97.0 | Elevated carcinoembryonic antigen [CEA] |
Z08 | Encounter for follow-up examination after completed treatment for malignant neoplasm |
Z51.1 | Encounter for antineoplastic chemotherapy and immunotherapy |
Z80.0 | Family history of malignant neoplasm of digestive organs |
Z80.1 | Family history of malignant neoplasm of trachea, bronchus and lung |
Z83.71 | Family history of colonic polyps |
Z85 | Personal history of malignant neoplasm |
Z85.0 | Personal history of malignant neoplasm of digestive organs |
Z85.038 | Personal history of other malignant neoplasm of large intestine |
Z85.04 | Personal history of malignant neoplasm of rectum, rectosigmoid junction, and anus |
Z85.048 | Personal history of other malignant neoplasm of rectum, rectosigmoid junction, and anus |
Z85.05 | Personal history of malignant neoplasm of liver |
Z85.1 | Personal history of malignant neoplasm of trachea, bronchus and lung |
Z85.11 | Personal history of malignant neoplasm of bronchus and lung |
Z85.110 | Personal history of malignant carcinoid tumor of bronchus and lung |
Z85.118 | Personal history of other malignant neoplasm of bronchus and lung |
Z85.820 | Personal history of malignant melanoma of skin |
Z85.850 | Personal history of malignant neoplasm of thyroid |
Z85.9 | Personal history of malignant neoplasm, unspecified |
Z86.004 | Personal history of in-situ neoplasm of other and unspecified digestive organs |
Z86.010 | Personal history of colonic polyps |
Z87.19 | Personal history of other diseases of the digestive system |
C18.0 | Malignant neoplasm of cecum |
C18.1 | Malignant neoplasm of appendix |
C18.2 | Malignant neoplasm of ascending colon |
C18.3 | Malignant neoplasm of hepatic flexure |
C18.4 | Malignant neoplasm of transverse colon |
C18.5 | Malignant neoplasm of splenic flexure |
C18.6 | Malignant neoplasm of descending colon |
C18.7 | Malignant neoplasm of sigmoid colon |
C18.8 | Malignant neoplasm of overlapping sites of colon |
C18.9 | Malignant neoplasm of colon, unspecified |
C21.0 | Malignant neoplasm of anus, unspecified |
C21.1 | Malignant neoplasm of anal canal |
C21.2 | Malignant neoplasm of cloacogenic zone |
C21.8 | Malignant neoplasm of overlapping sites of rectum, anus and anal canal |
C34.0 | Malignant neoplasm of main bronchus |
C34.00 | Malignant neoplasm of unspecified main bronchus |
C34.01 | Malignant neoplasm of right main bronchus |
C34.02 | Malignant neoplasm of left main bronchus |
C34.1 | Malignant neoplasm of upper lobe, bronchus or lung |
C34.10 | Malignant neoplasm of upper lobe, unspecified bronchus or lung |
C34.11 | Malignant neoplasm of upper lobe, right bronchus or lung |
C34.12 | Malignant neoplasm of upper lobe, left bronchus or lung |
C34.2 | Malignant neoplasm of middle lobe, bronchus or lung |
C34.3 | Malignant neoplasm of lower lobe, bronchus or lung |
C34.30 | Malignant neoplasm of lower lobe, unspecified bronchus or lung |
C34.31 | Malignant neoplasm of lower lobe, right bronchus or lung |
C34.32 | Malignant neoplasm of lower lobe, left bronchus or lung |
C34.8 | Malignant neoplasm of overlapping sites of bronchus and lung |
C34.80 | Malignant neoplasm of overlapping sites of unspecified bronchus and lung |
C34.81 | Malignant neoplasm of overlapping sites of right bronchus and lung |
C34.82 | Malignant neoplasm of overlapping sites of left bronchus and lung |
C34.9 | Malignant neoplasm of unspecified part of bronchus or lung |
C34.90 | Malignant neoplasm of unspecified part of unspecified bronchus or lung |
C34.91 | Malignant neoplasm of unspecified part of right bronchus or lung |
C34.92 | Malignant neoplasm of unspecified part of left bronchus or lung |
C43.0 | Malignant melanoma of lip |
C43.1 | Malignant melanoma of eyelid, including canthus |
C43.10 | Malignant melanoma of unspecified eyelid, including canthus |
C43.11 | Malignant melanoma of right eyelid, including canthus |
C43.111 | Malignant melanoma of right upper eyelid, including canthus |
C43.112 | Malignant melanoma of right lower eyelid, including canthus |
C43.12 | Malignant melanoma of left eyelid, including canthus |
C43.121 | Malignant melanoma of left upper eyelid, including canthus |
C43.122 | Malignant melanoma of left lower eyelid, including canthus |
C43.2 | Malignant melanoma of ear and external auricular canal |
C43.20 | Malignant melanoma of unspecified ear and external auricular canal |
C43.21 | Malignant melanoma of right ear and external auricular canal |
C43.22 | Malignant melanoma of left ear and external auricular canal |
C43.3 | Malignant melanoma of other and unspecified parts of face |
C43.30 | Malignant melanoma of unspecified part of face |
C43.31 | Malignant melanoma of nose |
C43.39 | Malignant melanoma of other parts of face |
C43.4 | Malignant melanoma of scalp and neck |
C43.5 | Malignant melanoma of trunk |
C43.51 | Malignant melanoma of anal skin |
C43.52 | Malignant melanoma of skin of breast |
C43.59 | Malignant melanoma of other part of trunk |
C43.6 | Malignant melanoma of upper limb, including shoulder |
C43.60 | Malignant melanoma of unspecified upper limb, including shoulder |
C43.61 | Malignant melanoma of right upper limb, including shoulder |
C43.62 | Malignant melanoma of left upper limb, including shoulder |
C43.7 | Malignant melanoma of lower limb, including hip |
C43.70 | Malignant melanoma of unspecified lower limb, including hip |
C43.71 | Malignant melanoma of right lower limb, including hip |
C43.72 | Malignant melanoma of left lower limb, including hip |
C43.8 | Malignant melanoma of overlapping sites of skin |
C43.9 | Malignant melanoma of skin, unspecified |
C71.0 | Malignant neoplasm of cerebrum, except lobes and ventricles |
C71.1 | Malignant neoplasm of frontal lobe |
C71.2 | Malignant neoplasm of temporal lobe |
C71.3 | Malignant neoplasm of parietal lobe |
C71.4 | Malignant neoplasm of occipital lobe |
C71.5 | Malignant neoplasm of cerebral ventricle |
C71.6 | Malignant neoplasm of cerebellum |
C71.7 | Malignant neoplasm of brain stem |
C71.8 | Malignant neoplasm of overlapping sites of brain |
C71.9 | Malignant neoplasm of brain, unspecified |
C75.0 | Malignant neoplasm of parathyroid gland |
C78.0 | Secondary malignant neoplasm of lung |
C78.00 | Secondary malignant neoplasm of unspecified lung |
C78.01 | Secondary malignant neoplasm of right lung |
C78.02 | Secondary malignant neoplasm of left lung |
C78.1 | Secondary malignant neoplasm of mediastinum |
C78.2 | Secondary malignant neoplasm of pleura |
C78.3 | Secondary malignant neoplasm of other and unspecified respiratory organs |
C78.30 | Secondary malignant neoplasm of unspecified respiratory organ |
C78.39 | Secondary malignant neoplasm of other respiratory organs |
C78.4 | Secondary malignant neoplasm of small intestine |
C78.5 | Secondary malignant neoplasm of large intestine and rectum |
C78.6 | Secondary malignant neoplasm of retroperitoneum and peritoneum |
C78.7 | Secondary malignant neoplasm of liver and intrahepatic bile duct |
C78.8 | Secondary malignant neoplasm of other and unspecified digestive organs |
C78.80 | Secondary malignant neoplasm of unspecified digestive organ |
C78.89 | Secondary malignant neoplasm of other digestive organs |
C7A.022 | Malignant carcinoid tumor of the ascending colon |
C7A.023 | Malignant carcinoid tumor of the transverse colon |
C7A.024 | Malignant carcinoid tumor of the descending colon |
C7A.025 | Malignant carcinoid tumor of the sigmoid colon |
C82.0 | Follicular lymphoma grade I |
C82.00 | Follicular lymphoma grade I, unspecified site |
C82.01 | Follicular lymphoma grade I, lymph nodes of head, face, and neck |
C82.02 | Follicular lymphoma grade I, intrathoracic lymph nodes |
C82.03 | Follicular lymphoma grade I, intra-abdominal lymph nodes |
C82.04 | Follicular lymphoma grade I, lymph nodes of axilla and upper limb |
C82.05 | Follicular lymphoma grade I, lymph nodes of inguinal region and lower limb |
C82.06 | Follicular lymphoma grade I, intrapelvic lymph nodes |
C82.07 | Follicular lymphoma grade I, spleen |
C82.08 | Follicular lymphoma grade I, lymph nodes of multiple sites |
C82.09 | Follicular lymphoma grade I, extranodal and solid organ sites |
C82.1 | Follicular lymphoma grade II |
C82.10 | Follicular lymphoma grade II, unspecified site |
C82.11 | Follicular lymphoma grade II, lymph nodes of head, face, and neck |
C82.12 | Follicular lymphoma grade II, intrathoracic lymph nodes |
C82.13 | Follicular lymphoma grade II, intra-abdominal lymph nodes |
C82.14 | Follicular lymphoma grade II, lymph nodes of axilla and upper limb |
C82.15 | Follicular lymphoma grade II, lymph nodes of inguinal region and lower limb |
C82.16 | Follicular lymphoma grade II, intrapelvic lymph nodes |
C82.17 | Follicular lymphoma grade II, spleen |
C82.18 | Follicular lymphoma grade II, lymph nodes of multiple sites |
C82.19 | Follicular lymphoma grade II, extranodal and solid organ sites |
C82.2 | Follicular lymphoma grade III, unspecified |
C82.20 | Follicular lymphoma grade III, unspecified, unspecified site |
C82.21 | Follicular lymphoma grade III, unspecified, lymph nodes of head, face, and neck |
C82.22 | Follicular lymphoma grade III, unspecified, intrathoracic lymph nodes |
C82.23 | Follicular lymphoma grade III, unspecified, intra-abdominal lymph nodes |
C82.24 | Follicular lymphoma grade III, unspecified, lymph nodes of axilla and upper limb |
C82.25 | Follicular lymphoma grade III, unspecified, lymph nodes of inguinal region and lower limb |
C82.26 | Follicular lymphoma grade III, unspecified, intrapelvic lymph nodes |
C82.27 | Follicular lymphoma grade III, unspecified, spleen |
C82.28 | Follicular lymphoma grade III, unspecified, lymph nodes of multiple sites |
C82.29 | Follicular lymphoma grade III, unspecified, extranodal and solid organ sites |
C82.3 | Follicular lymphoma grade IIIa |
C82.30 | Follicular lymphoma grade IIIa, unspecified site |
C82.31 | Follicular lymphoma grade IIIa, lymph nodes of head, face, and neck |
C82.32 | Follicular lymphoma grade IIIa, intrathoracic lymph nodes |
C82.33 | Follicular lymphoma grade IIIa, intra-abdominal lymph nodes |
C82.34 | Follicular lymphoma grade IIIa, lymph nodes of axilla and upper limb |
C82.35 | Follicular lymphoma grade IIIa, lymph nodes of inguinal region and lower limb |
C82.36 | Follicular lymphoma grade IIIa, intrapelvic lymph nodes |
C82.37 | Follicular lymphoma grade IIIa, spleen |
C82.38 | Follicular lymphoma grade IIIa, lymph nodes of multiple sites |
C82.39 | Follicular lymphoma grade IIIa, extranodal and solid organ sites |
C82.4 | Follicular lymphoma grade IIIb |
C82.40 | Follicular lymphoma grade IIIb, unspecified site |
C82.41 | Follicular lymphoma grade IIIb, lymph nodes of head, face, and neck |
C82.42 | Follicular lymphoma grade IIIb, intrathoracic lymph nodes |
C82.43 | Follicular lymphoma grade IIIb, intra-abdominal lymph nodes |
C82.44 | Follicular lymphoma grade IIIb, lymph nodes of axilla and upper limb |
C82.45 | Follicular lymphoma grade IIIb, lymph nodes of inguinal region and lower limb |
C82.46 | Follicular lymphoma grade IIIb, intrapelvic lymph nodes |
C82.47 | Follicular lymphoma grade IIIb, spleen |
C82.48 | Follicular lymphoma grade IIIb, lymph nodes of multiple sites |
C82.49 | Follicular lymphoma grade IIIb, extranodal and solid organ sites |
C82.5 | Diffuse follicle center lymphoma |
C82.50 | Diffuse follicle center lymphoma, unspecified site |
C82.51 | Diffuse follicle center lymphoma, lymph nodes of head, face, and neck |
C82.52 | Diffuse follicle center lymphoma, intrathoracic lymph nodes |
C82.53 | Diffuse follicle center lymphoma, intra-abdominal lymph nodes |
C82.54 | Diffuse follicle center lymphoma, lymph nodes of axilla and upper limb |
C82.55 | Diffuse follicle center lymphoma, lymph nodes of inguinal region and lower limb |
C82.56 | Diffuse follicle center lymphoma, intrapelvic lymph nodes |
C82.57 | Diffuse follicle center lymphoma, spleen |
C82.58 | Diffuse follicle center lymphoma, lymph nodes of multiple sites |
C82.59 | Diffuse follicle center lymphoma, extranodal and solid organ sites |
C82.6 | Cutaneous follicle center lymphoma |
C82.60 | Cutaneous follicle center lymphoma, unspecified site |
C82.61 | Cutaneous follicle center lymphoma, lymph nodes of head, face, and neck |
C82.62 | Cutaneous follicle center lymphoma, intrathoracic lymph nodes |
C82.63 | Cutaneous follicle center lymphoma, intra-abdominal lymph nodes |
C82.64 | Cutaneous follicle center lymphoma, lymph nodes of axilla and upper limb |
C82.65 | Cutaneous follicle center lymphoma, lymph nodes of inguinal region and lower limb |
C82.66 | Cutaneous follicle center lymphoma, intrapelvic lymph nodes |
C82.67 | Cutaneous follicle center lymphoma, spleen |
C82.68 | Cutaneous follicle center lymphoma, lymph nodes of multiple sites |
C82.69 | Cutaneous follicle center lymphoma, extranodal and solid organ sites |
C82.8 | Other types of follicular lymphoma |
C82.80 | Other types of follicular lymphoma, unspecified site |
C82.81 | Other types of follicular lymphoma, lymph nodes of head, face, and neck |
C82.82 | Other types of follicular lymphoma, intrathoracic lymph nodes |
C82.83 | Other types of follicular lymphoma, intra-abdominal lymph nodes |
C82.84 | Other types of follicular lymphoma, lymph nodes of axilla and upper limb |
C82.85 | Other types of follicular lymphoma, lymph nodes of inguinal region and lower limb |
C82.86 | Other types of follicular lymphoma, intrapelvic lymph nodes |
C82.87 | Other types of follicular lymphoma, spleen |
C82.88 | Other types of follicular lymphoma, lymph nodes of multiple sites |
C82.89 | Other types of follicular lymphoma, extranodal and solid organ sites |
C82.9 | Follicular lymphoma, unspecified |
C82.90 | Follicular lymphoma, unspecified, unspecified site |
C82.91 | Follicular lymphoma, unspecified, lymph nodes of head, face, and neck |
C82.92 | Follicular lymphoma, unspecified, intrathoracic lymph nodes |
C82.93 | Follicular lymphoma, unspecified, intra-abdominal lymph nodes |
C82.94 | Follicular lymphoma, unspecified, lymph nodes of axilla and upper limb |
C82.95 | Follicular lymphoma, unspecified, lymph nodes of inguinal region and lower limb |
C82.96 | Follicular lymphoma, unspecified, intrapelvic lymph nodes |
C82.97 | Follicular lymphoma, unspecified, spleen |
C82.98 | Follicular lymphoma, unspecified, lymph nodes of multiple sites |
C82.99 | Follicular lymphoma, unspecified, extranodal and solid organ sites |
C85.1 | Unspecified B-cell lymphoma |
C85.10 | Unspecified B-cell lymphoma, unspecified site |
C85.11 | Unspecified B-cell lymphoma, lymph nodes of head, face, and neck |
C85.12 | Unspecified B-cell lymphoma, intrathoracic lymph nodes |
C85.13 | Unspecified B-cell lymphoma, intra-abdominal lymph nodes |
C85.14 | Unspecified B-cell lymphoma, lymph nodes of axilla and upper limb |
C85.15 | Unspecified B-cell lymphoma, lymph nodes of inguinal region and lower limb |
C85.16 | Unspecified B-cell lymphoma, intrapelvic lymph nodes |
C85.17 | Unspecified B-cell lymphoma, spleen |
C85.18 | Unspecified B-cell lymphoma, lymph nodes of multiple sites |
C85.19 | Unspecified B-cell lymphoma, extranodal and solid organ sites |
C85.2 | Mediastinal (thymic) large B-cell lymphoma |
C85.20 | Mediastinal (thymic) large B-cell lymphoma, unspecified site |
C85.21 | Mediastinal (thymic) large B-cell lymphoma, lymph nodes of head, face, and neck |
C85.22 | Mediastinal (thymic) large B-cell lymphoma, intrathoracic lymph nodes |
C85.23 | Mediastinal (thymic) large B-cell lymphoma, intra-abdominal lymph nodes |
C85.24 | Mediastinal (thymic) large B-cell lymphoma, lymph nodes of axilla and upper limb |
C85.25 | Mediastinal (thymic) large B-cell lymphoma, lymph nodes of inguinal region and lower limb |
C85.26 | Mediastinal (thymic) large B-cell lymphoma, intrapelvic lymph nodes |
C85.27 | Mediastinal (thymic) large B-cell lymphoma, spleen |
C85.28 | Mediastinal (thymic) large B-cell lymphoma, lymph nodes of multiple sites |
C85.29 | Mediastinal (thymic) large B-cell lymphoma, extranodal and solid organ sites |
C85.8 | Other specified types of non-Hodgkin lymphoma |
C85.80 | Other specified types of non-Hodgkin lymphoma, unspecified site |
C85.81 | Other specified types of non-Hodgkin lymphoma, lymph nodes of head, face, and neck |
C85.82 | Other specified types of non-Hodgkin lymphoma, intrathoracic lymph nodes |
C85.83 | Other specified types of non-Hodgkin lymphoma, intra-abdominal lymph nodes |
C85.84 | Other specified types of non-Hodgkin lymphoma, lymph nodes of axilla and upper limb |
C85.85 | Other specified types of non-Hodgkin lymphoma, lymph nodes of inguinal region and lower limb |
C85.86 | Other specified types of non-Hodgkin lymphoma, intrapelvic lymph nodes |
C85.87 | Other specified types of non-Hodgkin lymphoma, spleen |
C85.88 | Other specified types of non-Hodgkin lymphoma, lymph nodes of multiple sites |
C85.89 | Other specified types of non-Hodgkin lymphoma, extranodal and solid organ sites |
C85.9 | Non-Hodgkin lymphoma, unspecified |
C85.90 | Non-Hodgkin lymphoma, unspecified, unspecified site |
C85.91 | Non-Hodgkin lymphoma, unspecified, lymph nodes of head, face, and neck |
C85.92 | Non-Hodgkin lymphoma, unspecified, intrathoracic lymph nodes |
C85.93 | Non-Hodgkin lymphoma, unspecified, intra-abdominal lymph nodes |
C85.94 | Non-Hodgkin lymphoma, unspecified, lymph nodes of axilla and upper limb |
C85.95 | Non-Hodgkin lymphoma, unspecified, lymph nodes of inguinal region and lower limb |
C85.96 | Non-Hodgkin lymphoma, unspecified, intrapelvic lymph nodes |
C85.97 | Non-Hodgkin lymphoma, unspecified, spleen |
C85.98 | Non-Hodgkin lymphoma, unspecified, lymph nodes of multiple sites |
C85.99 | Non-Hodgkin lymphoma, unspecified, extranodal and solid organ sites |
D01.0 | Carcinoma in situ of colon |
D03.0 | Melanoma in situ of lip |
D03.1 | Melanoma in situ of eyelid, including canthus |
D03.10 | Melanoma in situ of unspecified eyelid, including canthus |
D03.11 | Melanoma in situ of right eyelid, including canthus |
D03.111 | Melanoma in situ of right upper eyelid, including canthus |
D03.112 | Melanoma in situ of right lower eyelid, including canthus |
D03.12 | Melanoma in situ of left eyelid, including canthus |
D03.121 | Melanoma in situ of left upper eyelid, including canthus |
D03.122 | Melanoma in situ of left lower eyelid, including canthus |
D03.2 | Melanoma in situ of ear and external auricular canal |
D03.20 | Melanoma in situ of unspecified ear and external auricular canal |
D03.21 | Melanoma in situ of right ear and external auricular canal |
D03.22 | Melanoma in situ of left ear and external auricular canal |
D03.3 | Melanoma in situ of other and unspecified parts of face |
D03.30 | Melanoma in situ of unspecified part of face |
D03.39 | Melanoma in situ of other parts of face |
D03.4 | Melanoma in situ of scalp and neck |
D03.5 | Melanoma in situ of trunk |
D03.51 | Melanoma in situ of anal skin |
D03.52 | Melanoma in situ of breast (skin) (soft tissue) |
D03.59 | Melanoma in situ of other part of trunk |
D03.6 | Melanoma in situ of upper limb, including shoulder |
D03.60 | Melanoma in situ of unspecified upper limb, including shoulder |
D03.61 | Melanoma in situ of right upper limb, including shoulder |
D03.62 | Melanoma in situ of left upper limb, including shoulder |
D03.7 | Melanoma in situ of lower limb, including hip |
D03.70 | Melanoma in situ of unspecified lower limb, including hip |
D03.71 | Melanoma in situ of right lower limb, including hip |
D03.72 | Melanoma in situ of left lower limb, including hip |
D03.8 | Melanoma in situ of other sites |
D03.9 | Melanoma in situ, unspecified |
D12.0 | Benign neoplasm of cecum |
D12.1 | Benign neoplasm of appendix |
D12.2 | Benign neoplasm of ascending colon |
D12.3 | Benign neoplasm of transverse colon |
D12.4 | Benign neoplasm of descending colon |
D12.5 | Benign neoplasm of sigmoid colon |
D12.6 | Benign neoplasm of colon, unspecified |
D12.7 | Benign neoplasm of rectosigmoid junction |
D12.8 | Benign neoplasm of rectum |
D12.9 | Benign neoplasm of anus and anal canal |
D22.0 | Melanocytic nevi of lip |
D22.1 | Melanocytic nevi of eyelid, including canthus |
D22.10 | Melanocytic nevi of unspecified eyelid, including canthus |
D22.11 | Melanocytic nevi of right eyelid, including canthus |
D22.111 | Melanocytic nevi of right upper eyelid, including canthus |
D22.112 | Melanocytic nevi of right lower eyelid, including canthus |
D22.12 | Melanocytic nevi of left eyelid, including canthus |
D22.121 | Melanocytic nevi of left upper eyelid, including canthus |
D22.122 | Melanocytic nevi of left lower eyelid, including canthus |
D22.2 | Melanocytic nevi of ear and external auricular canal |
D22.20 | Melanocytic nevi of unspecified ear and external auricular canal |
D22.21 | Melanocytic nevi of right ear and external auricular canal |
D22.22 | Melanocytic nevi of left ear and external auricular canal |
D22.3 | Melanocytic nevi of other and unspecified parts of face |
D22.30 | Melanocytic nevi of unspecified part of face |
D22.39 | Melanocytic nevi of other parts of face |
D22.4 | Melanocytic nevi of scalp and neck |
D22.5 | Melanocytic nevi of trunk |
D22.6 | Melanocytic nevi of upper limb, including shoulder |
D22.60 | Melanocytic nevi of unspecified upper limb, including shoulder |
D22.61 | Melanocytic nevi of right upper limb, including shoulder |
D22.62 | Melanocytic nevi of left upper limb, including shoulder |
D22.7 | Melanocytic nevi of lower limb, including hip |
D22.70 | Melanocytic nevi of unspecified lower limb, including hip |
D22.71 | Melanocytic nevi of right lower limb, including hip |
D22.72 | Melanocytic nevi of left lower limb, including hip |
D22.9 | Melanocytic nevi, unspecified |
D33.0 | Benign neoplasm of brain, supratentorial |
D33.1 | Benign neoplasm of brain, infratentorial |
D33.2 | Benign neoplasm of brain, unspecified |
D33.3 | Benign neoplasm of cranial nerves |
D33.4 | Benign neoplasm of spinal cord |
D33.7 | Benign neoplasm of other specified parts of central nervous system |
D33.9 | Benign neoplasm of central nervous system, unspecified |
D35.1 | Benign neoplasm of parathyroid gland |
D37.4 | Neoplasm of uncertain behavior of colon |
D3A.0 | Benign carcinoid tumors |
D3A.00 | Benign carcinoid tumor of unspecified site |
D3A.01 | Benign carcinoid tumors of the small intestine |
D3A.010 | Benign carcinoid tumor of the duodenum |
D3A.011 | Benign carcinoid tumor of the jejunum |
D3A.012 | Benign carcinoid tumor of the ileum |
D3A.019 | Benign carcinoid tumor of the small intestine, unspecified portion |
D3A.02 | Benign carcinoid tumors of the appendix, large intestine, and rectum |
D3A.020 | Benign carcinoid tumor of the appendix |
D3A.021 | Benign carcinoid tumor of the cecum |
D3A.022 | Benign carcinoid tumor of the ascending colon |
D3A.023 | Benign carcinoid tumor of the transverse colon |
D3A.024 | Benign carcinoid tumor of the descending colon |
D3A.025 | Benign carcinoid tumor of the sigmoid colon |
D3A.026 | Benign carcinoid tumor of the rectum |
D3A.029 | Benign carcinoid tumor of the large intestine, unspecified portion |
D3A.09 | Benign carcinoid tumors of other sites |
D3A.090 | Benign carcinoid tumor of the bronchus and lung |
D3A.091 | Benign carcinoid tumor of the thymus |
D3A.092 | Benign carcinoid tumor of the stomach |
D3A.093 | Benign carcinoid tumor of the kidney |
D3A.094 | Benign carcinoid tumor of the foregut, unspecified |
D3A.095 | Benign carcinoid tumor of the midgut, unspecified |
D3A.096 | Benign carcinoid tumor of the hindgut, unspecified |
D3A.098 | Benign carcinoid tumors of other sites |
D3A.8 | Other benign neuroendocrine tumors |
D44.0 | Neoplasm of uncertain behavior of thyroid gland |
D44.1 | Neoplasm of uncertain behavior of adrenal gland |
D44.10 | Neoplasm of uncertain behavior of unspecified adrenal gland |
D44.11 | Neoplasm of uncertain behavior of right adrenal gland |
D44.12 | Neoplasm of uncertain behavior of left adrenal gland |
D44.2 | Neoplasm of uncertain behavior of parathyroid gland |
D44.3 | Neoplasm of uncertain behavior of pituitary gland |
D44.4 | Neoplasm of uncertain behavior of craniopharyngeal duct |
D44.5 | Neoplasm of uncertain behavior of pineal gland |
D44.6 | Neoplasm of uncertain behavior of carotid body |
D44.7 | Neoplasm of uncertain behavior of aortic body and other paraganglia |
D44.9 | Neoplasm of uncertain behavior of unspecified endocrine gland |
D48.0 | Neoplasm of uncertain behavior of bone and articular cartilage |
D48.1 | Neoplasm of uncertain behavior of connective and other soft tissue |
D48.2 | Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system |
D48.3 | Neoplasm of uncertain behavior of retroperitoneum |
D48.4 | Neoplasm of uncertain behavior of peritoneum |
D48.5 | Neoplasm of uncertain behavior of skin |
D48.6 | Neoplasm of uncertain behavior of breast |
D48.60 | Neoplasm of uncertain behavior of unspecified breast |
D48.61 | Neoplasm of uncertain behavior of right breast |
D48.62 | Neoplasm of uncertain behavior of left breast |
D48.7 | Neoplasm of uncertain behavior of other specified sites |
D48.9 | Neoplasm of uncertain behavior, unspecified |
D49.0 | Neoplasm of unspecified behavior of digestive system |
D49.1 | Neoplasm of unspecified behavior of respiratory system |
D49.2 | Neoplasm of unspecified behavior of bone, soft tissue, and skin |
D49.3 | Neoplasm of unspecified behavior of breast |
D49.4 | Neoplasm of unspecified behavior of bladder |
D49.5 | Neoplasm of unspecified behavior of other genitourinary organs |
D49.51 | Neoplasm of unspecified behavior of kidney |
D49.511 | Neoplasm of unspecified behavior of right kidney |
D49.512 | Neoplasm of unspecified behavior of left kidney |
D49.519 | Neoplasm of unspecified behavior of unspecified kidney |
D49.59 | Neoplasm of unspecified behavior of other genitourinary organ |
D49.6 | Neoplasm of unspecified behavior of brain |
D49.7 | Neoplasm of unspecified behavior of endocrine glands and other parts of nervous system |
D49.8 | Neoplasm of unspecified behavior of other specified sites |
D49.81 | Neoplasm of unspecified behavior of retina and choroid |
D49.89 | Neoplasm of unspecified behavior of other specified sites |
D49.9 | Neoplasm of unspecified behavior of unspecified site |
D61.810 | Antineoplastic chemotherapy induced pancytopenia |
D64.81 | Anemia due to antineoplastic chemotherapy |
D70.1 | Agranulocytosis secondary to cancer chemotherapy |
E31.0 | Autoimmune polyglandular failure |
E31.1 | Polyglandular hyperfunction |
E31.2 | Multiple endocrine neoplasia [MEN] syndromes |
E31.20 | Multiple endocrine neoplasia [MEN] syndrome, unspecified |
E31.21 | Multiple endocrine neoplasia [MEN] type I |
E31.22 | Multiple endocrine neoplasia [MEN] type IIA |
E31.23 | Multiple endocrine neoplasia [MEN] type IIB |
E31.8 | Other polyglandular dysfunction |
E31.9 | Polyglandular dysfunction, unspecified |
K63.5 | Polyp of colon |
P04.11 | Newborn affected by maternal antineoplastic chemotherapy |
R91.1 | Solitary pulmonary nodule |
R91.8 | Other nonspecific abnormal finding of lung field |
R97.0 | Elevated carcinoembryonic antigen [CEA] |
R97.1 | Elevated cancer antigen 125 [CA 125] |
R97.2 | Elevated prostate specific antigen [PSA] |
R97.20 | Elevated prostate specific antigen [PSA] |
R97.21 | Rising PSA following treatment for malignant neoplasm of prostate |
R97.8 | Other abnormal tumor markers |
T80.810 | Extravasation of vesicant antineoplastic chemotherapy |
T80.810A | Extravasation of vesicant antineoplastic chemotherapy, initial encounter |
T80.810D | Extravasation of vesicant antineoplastic chemotherapy, subsequent encounter |
T80.810S | Extravasation of vesicant antineoplastic chemotherapy, sequela |
Z12.11 | Encounter for screening for malignant neoplasm of colon |
Z51.1 | Encounter for antineoplastic chemotherapy and immunotherapy |
Z51.11 | Encounter for antineoplastic chemotherapy |
Z83.71 | Family history of colonic polyps |
Z85.0 | Personal history of malignant neoplasm of digestive organs |
Z85.00 | Personal history of malignant neoplasm of unspecified digestive organ |
Z85.01 | Personal history of malignant neoplasm of esophagus |
Z85.02 | Personal history of malignant neoplasm of stomach |
Z85.020 | Personal history of malignant carcinoid tumor of stomach |
Z85.028 | Personal history of other malignant neoplasm of stomach |
Z85.03 | Personal history of malignant neoplasm of large intestine |
Z85.030 | Personal history of malignant carcinoid tumor of large intestine |
Z85.038 | Personal history of other malignant neoplasm of large intestine |
Z85.04 | Personal history of malignant neoplasm of rectum, rectosigmoid junction, and anus |
Z85.040 | Personal history of malignant carcinoid tumor of rectum |
Z85.048 | Personal history of other malignant neoplasm of rectum, rectosigmoid junction, and anus |
Z85.05 | Personal history of malignant neoplasm of liver |
Z85.06 | Personal history of malignant neoplasm of small intestine |
Z85.060 | Personal history of malignant carcinoid tumor of small intestine |
Z85.068 | Personal history of other malignant neoplasm of small intestine |
Z85.07 | Personal history of malignant neoplasm of pancreas |
Z85.09 | Personal history of malignant neoplasm of other digestive organs |
Z85.1 | Personal history of malignant neoplasm of trachea, bronchus and lung |
Z85.11 | Personal history of malignant neoplasm of bronchus and lung |
Z85.110 | Personal history of malignant carcinoid tumor of bronchus and lung |
Z85.118 | Personal history of other malignant neoplasm of bronchus and lung |
Z85.12 | Personal history of malignant neoplasm of trachea |
Z85.2 | Personal history of malignant neoplasm of other respiratory and intrathoracic organs |
Z85.20 | Personal history of malignant neoplasm of unspecified respiratory organ |
Z85.21 | Personal history of malignant neoplasm of larynx |
Z85.22 | Personal history of malignant neoplasm of nasal cavities, middle ear, and accessory sinuses |
Z85.23 | Personal history of malignant neoplasm of thymus |
Z85.230 | Personal history of malignant carcinoid tumor of thymus |
Z85.238 | Personal history of other malignant neoplasm of thymus |
Z85.29 | Personal history of malignant neoplasm of other respiratory and intrathoracic organs |
Z85.3 | Personal history of malignant neoplasm of breast |
Z85.4 | Personal history of malignant neoplasm of genital organs |
Z85.40 | Personal history of malignant neoplasm of unspecified female genital organ |
Z85.41 | Personal history of malignant neoplasm of cervix uteri |
Z85.42 | Personal history of malignant neoplasm of other parts of uterus |
Z85.43 | Personal history of malignant neoplasm of ovary |
Z85.44 | Personal history of malignant neoplasm of other female genital organs |
Z85.45 | Personal history of malignant neoplasm of unspecified male genital organ |
Z85.46 | Personal history of malignant neoplasm of prostate |
Z85.47 | Personal history of malignant neoplasm of testis |
Z85.48 | Personal history of malignant neoplasm of epididymis |
Z85.49 | Personal history of malignant neoplasm of other male genital organs |
Z85.5 | Personal history of malignant neoplasm of urinary tract |
Z85.50 | Personal history of malignant neoplasm of unspecified urinary tract organ |
Z85.51 | Personal history of malignant neoplasm of bladder |
Z85.52 | Personal history of malignant neoplasm of kidney |
Z85.520 | Personal history of malignant carcinoid tumor of kidney |
Z85.528 | Personal history of other malignant neoplasm of kidney |
Z85.53 | Personal history of malignant neoplasm of renal pelvis |
Z85.54 | Personal history of malignant neoplasm of ureter |
Z85.59 | Personal history of malignant neoplasm of other urinary tract organ |
Z85.6 | Personal history of leukemia |
Z85.7 | Personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues |
Z85.71 | Personal history of Hodgkin lymphoma |
Z85.72 | Personal history of non-Hodgkin lymphomas |
Z85.79 | Personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues |
Z85.8 | Personal history of malignant neoplasms of other organs and systems |
Z85.81 | Personal history of malignant neoplasm of lip, oral cavity, and pharynx |
Z85.810 | Personal history of malignant neoplasm of tongue |
Z85.818 | Personal history of malignant neoplasm of other sites of lip, oral cavity, and pharynx |
Z85.819 | Personal history of malignant neoplasm of unspecified site of lip, oral cavity, and pharynx |
Z85.82 | Personal history of malignant neoplasm of skin |
Z85.820 | Personal history of malignant melanoma of skin |
Z85.821 | Personal history of Merkel cell carcinoma |
Z85.828 | Personal history of other malignant neoplasm of skin |
Z85.83 | Personal history of malignant neoplasm of bone and soft tissue |
Z85.830 | Personal history of malignant neoplasm of bone |
Z85.831 | Personal history of malignant neoplasm of soft tissue |
Z85.84 | Personal history of malignant neoplasm of eye and nervous tissue |
Z85.840 | Personal history of malignant neoplasm of eye |
Z85.841 | Personal history of malignant neoplasm of brain |
Z85.848 | Personal history of malignant neoplasm of other parts of nervous tissue |
Z85.85 | Personal history of malignant neoplasm of endocrine glands |
Z85.850 | Personal history of malignant neoplasm of thyroid |
Z85.858 | Personal history of malignant neoplasm of other endocrine glands |
Z85.89 | Personal history of malignant neoplasm of other organs and systems |
Z85.9 | Personal history of malignant neoplasm, unspecified |
Z86.010 | Personal history of colonic polyps |
Z86.011 | Personal history of benign neoplasm of the brain |
Z92.21 | Personal history of antineoplastic chemotherapy |