Diseases (27)
Screening/Initial Testing (7)

Note:

Should be performed on both maternal and infant samples


Note:

If syphilis is suspected by history


Note:

Rule out syphilis.

Diagnostic Testing (14)

Note:

Rule out syphilis in patients with patchy alopecia


Note:

If T. pallidum serology is positive.


Note:

Rule out syphilis.


Note:

Should be ordered with VDRL as VDRL is usually positive and RPR negative.

Overview

Treponema pallidum, the etiological agent of syphilis, induces the production of at least two types of antibodies in human infection: anti-treponemal antibodies that can be detected by fluorescence treponemal antigen assay (FTA-ABS), and anti-nontreponemal antibodies (reagin) that can be detected by RPR antigen. RPR is a latex flocculation based test that uses a cardiolipin-lecithin-cholesterol carbon-containing antigen reagent. If antibodies are present, black carbon clumps are produced by flocculation indicating a positive test for RPR. It is a rapid test used as a screening test and in suspected primary and secondary syphilis. It is not specific for syphilis and false positives can occur with disorders such as malaria, systemic lupus erythematosus, infectious mononucleosis, viral pneumonia as well as the status of being pregnant.  Positive results must be confirmed by IFA antibody testing or by PCR. The test is also used for treatment monitoring and disease management. After treatment with antibiotics, the levels of syphilis antibodies should fall. These levels can be monitored with the RPR titer.  Successful therapy is indicated by a 4 fold decrease in titer within 6 months after initiation of therapy for primary and secondary stages.  Unchanged or rising levels can mean a persistent infection.

Syphilis is a sexually transmitted infection (STI) caused by the bacterial spirochete Treponema pallidum. Syphilis can be divided into three infectious stages: primary, secondary, and early latent, and two non-infectious disease stages: late latent and tertiary. Untreated syphilis during pregnancy can lead to miscarriage, premature or stillbirth, and birth defects. Testing of the mother is very important during the early stages of pregnancy so that treatment can be administered and the fetus can remain unaffected. It is estimated that approximately 12 million new cases of venereal syphilis occur each year.

Clinical Utility
  • Diagnosis of syphilis
  • Screening test for syphilis
  • Therapy monitoring

Interpretation

Increased in:

  • Syphilis: primary in about 80%
  • Secondary >95%
  • Symptomatic late syphilis in about 75%

False positives:

  • Leprosy
  • Malaria
  • Intravenous Drug Abuse
  • Infectious Mononucleosis
  • HIV infection (15%)
  • Autoimmune Diseases such as SLE and Rheumatoid Arthritis
  • Occasional false positives in elderly and pregnancy

Reference Ranges

Negative (Non-reactive)


 

 

Methodology

Macroscopic agglutination.

Specimen Collection

Serum (Red top) preferred, Serum gel (SST) acceptable

Stability:

  • Ambient: 4 days
  • Refrigerated: 7 days
  • Frozen: 30 days

Additional Testing

Treponemal antibody by IFA or ELISA, T. pallidum by PCR testing, MHA-TP.

CPT
86593$ 4.4

ICD10
A50Congenital syphilis
A50.1Early congenital syphilis, latent
A50.4Late congenital neurosyphilis [juvenile neurosyphilis]
A50.40Late congenital neurosyphilis, unspecified
A50.49Other late congenital neurosyphilis
A50.6Late congenital syphilis, latent
A50.7Late congenital syphilis, unspecified
A50.9Congenital syphilis, unspecified
A51Early syphilis
A51.0Primary genital syphilis
A51.3Secondary syphilis of skin and mucous membranes
A51.32Syphilitic alopecia
A51.39Other secondary syphilis of skin
A51.4Other secondary syphilis
A51.41Secondary syphilitic meningitis
A51.42Secondary syphilitic female pelvic disease
A51.49Other secondary syphilitic conditions
A51.5Early syphilis, latent
A52Late syphilis
A52.1Symptomatic neurosyphilis
A52.10Symptomatic neurosyphilis, unspecified
A52.19Other symptomatic neurosyphilis
A52.3Neurosyphilis, unspecified
A52.7Other symptomatic late syphilis
A52.79Other symptomatic late syphilis
A52.8Late syphilis, latent
A53Other and unspecified syphilis
A53.0Latent syphilis, unspecified as early or late
A53.9Syphilis, unspecified
A56Other sexually transmitted chlamydial diseases
A56.11Chlamydial female pelvic inflammatory disease
A56.8Sexually transmitted chlamydial infection of other sites
A60Anogenital herpesviral [herpes simplex] infections
A60.0Herpesviral infection of genitalia and urogenital tract
A60.00Herpesviral infection of urogenital system, unspecified
A60.01Herpesviral infection of penis
A60.02Herpesviral infection of other male genital organs
A60.03Herpesviral cervicitis
A60.04Herpesviral vulvovaginitis
A60.09Herpesviral infection of other urogenital tract
A60.1Herpesviral infection of perianal skin and rectum
A60.9Anogenital herpesviral infection, unspecified
B00Herpesviral [herpes simplex] infections
B00.0Eczema herpeticum
B00.1Herpesviral vesicular dermatitis
B00.3Herpesviral meningitis
B00.4Herpesviral encephalitis
B00.5Herpesviral ocular disease
B00.53Herpesviral conjunctivitis
B00.81Herpesviral hepatitis
B00.82Herpes simplex myelitis
B00.89Other herpesviral infection
B00.9Herpesviral infection, unspecified
B02Zoster [herpes zoster]
B02.23Postherpetic polyneuropathy
D68Other coagulation defects
D68.61Antiphospholipid syndrome
D68.62Lupus anticoagulant syndrome
F01Vascular dementia
F02Dementia in other diseases classified elsewhere
F03Unspecified dementia
F03.90Unspecified dementia without behavioral disturbance
F03.91Unspecified dementia with behavioral disturbance
F10.27Alcohol dependence with alcohol-induced persisting dementia
F18.17Inhalant abuse with inhalant-induced dementia
G31.84Mild cognitive impairment, so stated
G58Other mononeuropathies
G58.9Mononeuropathy, unspecified
G60Hereditary and idiopathic neuropathy
G60.0Hereditary motor and sensory neuropathy
G60.3Idiopathic progressive neuropathy
G60.8Other hereditary and idiopathic neuropathies
G61Inflammatory polyneuropathy
G61.1Serum neuropathy
G62Other and unspecified polyneuropathies
G62.9Polyneuropathy, unspecified
G63Polyneuropathy in diseases classified elsewhere
G90.0Idiopathic peripheral autonomic neuropathy
G99Other disorders of nervous system in diseases classified elsewhere
G99.0Autonomic neuropathy in diseases classified elsewhere
I32Pericarditis in diseases classified elsewhere
I39Endocarditis and heart valve disorders in diseases classified elsewhere
I40Acute myocarditis
I40.0Infective myocarditis
I40.1Isolated myocarditis
I40.8Other acute myocarditis
I40.9Acute myocarditis, unspecified
I41Myocarditis in diseases classified elsewhere
I73Other peripheral vascular diseases
I73.0Raynaud's syndrome
I73.00Raynaud's syndrome without gangrene
I73.01Raynaud's syndrome with gangrene
J39Other diseases of upper respiratory tract
J99Respiratory disorders in diseases classified elsewhere
L63Alopecia areata
L63.0Alopecia (capitis) totalis
L63.1Alopecia universalis
L63.8Other alopecia areata
L63.9Alopecia areata, unspecified
L64Androgenic alopecia
L64.0Drug-induced androgenic alopecia
L64.8Other androgenic alopecia
L64.9Androgenic alopecia, unspecified
L65Other nonscarring hair loss
L65.2Alopecia mucinosa
L66Cicatricial alopecia [scarring hair loss]
L66.8Other cicatricial alopecia
L66.9Cicatricial alopecia, unspecified
L93Lupus erythematosus
L93.0Discoid lupus erythematosus
L93.1Subacute cutaneous lupus erythematosus
L93.2Other local lupus erythematosus
M32Systemic lupus erythematosus (SLE)
M32.0Drug-induced systemic lupus erythematosus
M32.10Systemic lupus erythematosus, organ or system involvement unspecified
M32.8Other forms of systemic lupus erythematosus
M32.9Systemic lupus erythematosus, unspecified
N08Glomerular disorders in diseases classified elsewhere
N16Renal tubulo-interstitial disorders in diseases classified elsewhere
N70Salpingitis and oophoritis
N72Inflammatory disease of cervix uteri
N73Other female pelvic inflammatory diseases
N73.0Acute parametritis and pelvic cellulitis
N73.3Female acute pelvic peritonitis
N73.9Female pelvic inflammatory disease, unspecified
N74Female pelvic inflammatory disorders in diseases classified elsewhere
N88Other noninflammatory disorders of cervix uteri
N89Other noninflammatory disorders of vagina
N90Other noninflammatory disorders of vulva and perineum
O09Supervision of high risk pregnancy
O26Maternal care for other conditions predominantly related to pregnancy
O36.01Maternal care for anti-D [Rh] antibodies
O98Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
O98.1Syphilis complicating pregnancy, childbirth and the puerperium
O98.51Other viral diseases complicating pregnancy
O98.52Other viral diseases complicating childbirth
O98.53Other viral diseases complicating the puerperium
O99.01Anemia complicating pregnancy
O99.280Endocrine, nutritional and metabolic diseases complicating pregnancy, unspecified trimester
O9A.41Sexual abuse complicating pregnancy
O9A.42Sexual abuse complicating childbirth
Q84.0Congenital alopecia
R41Other symptoms and signs involving cognitive functions and awareness
R43.0Anosmia
T74.2Sexual abuse, confirmed
T74.21Adult sexual abuse, confirmed
T74.21XAAdult sexual abuse, confirmed, initial encounter
T74.22Child sexual abuse, confirmed
T76.2Sexual abuse, suspected
T76.21Adult sexual abuse, suspected
T76.21XAAdult sexual abuse, suspected, initial encounter
T76.21XDAdult sexual abuse, suspected, subsequent encounter
T76.21XSAdult sexual abuse, suspected, sequela
T76.22Child sexual abuse, suspected
T76.22XAChild sexual abuse, suspected, initial encounter
T76.22XDChild sexual abuse, suspected, subsequent encounter
T86Complications of transplanted organs and tissue
T86.4Complications of liver transplant
T86.40Unspecified complication of liver transplant
T86.41Liver transplant rejection
T86.42Liver transplant failure
T86.43Liver transplant infection
T86.49Other complications of liver transplant
Z04.4Encounter for examination and observation following alleged rape
Z04.41Encounter for examination and observation following alleged adult rape
Z04.42Encounter for examination and observation following alleged child rape
Z34Encounter for supervision of normal pregnancy
Z34.8Encounter for supervision of other normal pregnancy
Z48.23Encounter for aftercare following liver transplant
Z94.4Liver transplant status

Additional ICD10
A38.1Scarlet fever with myocarditis
A39.52Meningococcal myocarditis
A50.0Early congenital syphilis, symptomatic
A50.01Early congenital syphilitic oculopathy
A50.02Early congenital syphilitic osteochondropathy
A50.03Early congenital syphilitic pharyngitis
A50.04Early congenital syphilitic pneumonia
A50.05Early congenital syphilitic rhinitis
A50.06Early cutaneous congenital syphilis
A50.07Early mucocutaneous congenital syphilis
A50.08Early visceral congenital syphilis
A50.09Other early congenital syphilis, symptomatic
A50.1Early congenital syphilis, latent
A50.2Early congenital syphilis, unspecified
A50.3Late congenital syphilitic oculopathy
A50.30Late congenital syphilitic oculopathy, unspecified
A50.31Late congenital syphilitic interstitial keratitis
A50.32Late congenital syphilitic chorioretinitis
A50.39Other late congenital syphilitic oculopathy
A50.4Late congenital neurosyphilis [juvenile neurosyphilis]
A50.40Late congenital neurosyphilis, unspecified
A50.41Late congenital syphilitic meningitis
A50.42Late congenital syphilitic encephalitis
A50.43Late congenital syphilitic polyneuropathy
A50.44Late congenital syphilitic optic nerve atrophy
A50.45Juvenile general paresis
A50.49Other late congenital neurosyphilis
A50.5Other late congenital syphilis, symptomatic
A50.51Clutton's joints
A50.52Hutchinson's teeth
A50.53Hutchinson's triad
A50.54Late congenital cardiovascular syphilis
A50.55Late congenital syphilitic arthropathy
A50.56Late congenital syphilitic osteochondropathy
A50.57Syphilitic saddle nose
A50.59Other late congenital syphilis, symptomatic
A50.6Late congenital syphilis, latent
A50.7Late congenital syphilis, unspecified
A50.9Congenital syphilis, unspecified
A51.0Primary genital syphilis
A51.1Primary anal syphilis
A51.2Primary syphilis of other sites
A51.3Secondary syphilis of skin and mucous membranes
A51.31Condyloma latum
A51.32Syphilitic alopecia
A51.39Other secondary syphilis of skin
A51.4Other secondary syphilis
A51.41Secondary syphilitic meningitis
A51.42Secondary syphilitic female pelvic disease
A51.43Secondary syphilitic oculopathy
A51.44Secondary syphilitic nephritis
A51.45Secondary syphilitic hepatitis
A51.46Secondary syphilitic osteopathy
A51.49Other secondary syphilitic conditions
A51.5Early syphilis, latent
A51.9Early syphilis, unspecified
A52.0Cardiovascular and cerebrovascular syphilis
A52.00Cardiovascular syphilis, unspecified
A52.01Syphilitic aneurysm of aorta
A52.02Syphilitic aortitis
A52.03Syphilitic endocarditis
A52.04Syphilitic cerebral arteritis
A52.05Other cerebrovascular syphilis
A52.06Other syphilitic heart involvement
A52.09Other cardiovascular syphilis
A52.1Symptomatic neurosyphilis
A52.10Symptomatic neurosyphilis, unspecified
A52.11Tabes dorsalis
A52.12Other cerebrospinal syphilis
A52.13Late syphilitic meningitis
A52.14Late syphilitic encephalitis
A52.15Late syphilitic neuropathy
A52.16Charcot's arthropathy (tabetic)
A52.17General paresis
A52.19Other symptomatic neurosyphilis
A52.2Asymptomatic neurosyphilis
A52.3Neurosyphilis, unspecified
A52.7Other symptomatic late syphilis
A52.71Late syphilitic oculopathy
A52.72Syphilis of lung and bronchus
A52.73Symptomatic late syphilis of other respiratory organs
A52.74Syphilis of liver and other viscera
A52.75Syphilis of kidney and ureter
A52.76Other genitourinary symptomatic late syphilis
A52.77Syphilis of bone and joint
A52.78Syphilis of other musculoskeletal tissue
A52.79Other symptomatic late syphilis
A52.8Late syphilis, latent
A52.9Late syphilis, unspecified
A53.0Latent syphilis, unspecified as early or late
A53.9Syphilis, unspecified
A56.0Chlamydial infection of lower genitourinary tract
A56.00Chlamydial infection of lower genitourinary tract, unspecified
A56.01Chlamydial cystitis and urethritis
A56.02Chlamydial vulvovaginitis
A56.09Other chlamydial infection of lower genitourinary tract
A56.1Chlamydial infection of pelviperitoneum and other genitourinary organs
A56.11Chlamydial female pelvic inflammatory disease
A56.19Other chlamydial genitourinary infection
A56.2Chlamydial infection of genitourinary tract, unspecified
A56.3Chlamydial infection of anus and rectum
A56.4Chlamydial infection of pharynx
A56.8Sexually transmitted chlamydial infection of other sites
A60.0Herpesviral infection of genitalia and urogenital tract
A60.00Herpesviral infection of urogenital system, unspecified
A60.01Herpesviral infection of penis
A60.02Herpesviral infection of other male genital organs
A60.03Herpesviral cervicitis
A60.04Herpesviral vulvovaginitis
A60.09Herpesviral infection of other urogenital tract
A60.1Herpesviral infection of perianal skin and rectum
A60.9Anogenital herpesviral infection, unspecified
B00.0Eczema herpeticum
B00.1Herpesviral vesicular dermatitis
B00.2Herpesviral gingivostomatitis and pharyngotonsillitis
B00.3Herpesviral meningitis
B00.4Herpesviral encephalitis
B00.5Herpesviral ocular disease
B00.50Herpesviral ocular disease, unspecified
B00.51Herpesviral iridocyclitis
B00.52Herpesviral keratitis
B00.53Herpesviral conjunctivitis
B00.59Other herpesviral disease of eye
B00.7Disseminated herpesviral disease
B00.8Other forms of herpesviral infections
B00.81Herpesviral hepatitis
B00.82Herpes simplex myelitis
B00.89Other herpesviral infection
B00.9Herpesviral infection, unspecified
B02.0Zoster encephalitis
B02.1Zoster meningitis
B02.2Zoster with other nervous system involvement
B02.21Postherpetic geniculate ganglionitis
B02.22Postherpetic trigeminal neuralgia
B02.23Postherpetic polyneuropathy
B02.24Postherpetic myelitis
B02.29Other postherpetic nervous system involvement
B02.3Zoster ocular disease
B02.30Zoster ocular disease, unspecified
B02.31Zoster conjunctivitis
B02.32Zoster iridocyclitis
B02.33Zoster keratitis
B02.34Zoster scleritis
B02.39Other herpes zoster eye disease
B02.7Disseminated zoster
B02.8Zoster with other complications
B02.9Zoster without complications
B26.82Mumps myocarditis
B33.22Viral myocarditis
B58.81Toxoplasma myocarditis
D68.2Hereditary deficiency of other clotting factors
D68.3Hemorrhagic disorder due to circulating anticoagulants
D68.31Hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
D68.312Antiphospholipid antibody with hemorrhagic disorder
D68.318Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
D68.32Hemorrhagic disorder due to extrinsic circulating anticoagulants
D68.4Acquired coagulation factor deficiency
D68.5Primary thrombophilia
D68.51Activated protein C resistance
D68.52Prothrombin gene mutation
D68.59Other primary thrombophilia
D68.6Other thrombophilia
D68.61Antiphospholipid syndrome
D68.62Lupus anticoagulant syndrome
D68.69Other thrombophilia
D68.8Other specified coagulation defects
D68.9Coagulation defect, unspecified
D86.85Sarcoid myocarditis
F01.5Vascular dementia
F01.50Vascular dementia without behavioral disturbance
F01.51Vascular dementia with behavioral disturbance
F02.8Dementia in other diseases classified elsewhere
F02.80Dementia in other diseases classified elsewhere without behavioral disturbance
F02.81Dementia in other diseases classified elsewhere with behavioral disturbance
F03.9Unspecified dementia
F03.90Unspecified dementia without behavioral disturbance
F03.91Unspecified dementia with behavioral disturbance
G58.0Intercostal neuropathy
G58.7Mononeuritis multiplex
G58.8Other specified mononeuropathies
G58.9Mononeuropathy, unspecified
G60.0Hereditary motor and sensory neuropathy
G60.1Refsum's disease
G60.2Neuropathy in association with hereditary ataxia
G60.3Idiopathic progressive neuropathy
G60.8Other hereditary and idiopathic neuropathies
G60.9Hereditary and idiopathic neuropathy, unspecified
G61.0Guillain-Barre syndrome
G61.1Serum neuropathy
G61.8Other inflammatory polyneuropathies
G61.81Chronic inflammatory demyelinating polyneuritis
G61.82Multifocal motor neuropathy
G61.89Other inflammatory polyneuropathies
G61.9Inflammatory polyneuropathy, unspecified
G62.0Drug-induced polyneuropathy
G62.1Alcoholic polyneuropathy
G62.2Polyneuropathy due to other toxic agents
G62.8Other specified polyneuropathies
G62.81Critical illness polyneuropathy
G62.82Radiation-induced polyneuropathy
G62.89Other specified polyneuropathies
G62.9Polyneuropathy, unspecified
G99.0Autonomic neuropathy in diseases classified elsewhere
G99.2Myelopathy in diseases classified elsewhere
G99.8Other specified disorders of nervous system in diseases classified elsewhere
I01.2Acute rheumatic myocarditis
I09.0Rheumatic myocarditis
I40.0Infective myocarditis
I40.1Isolated myocarditis
I40.8Other acute myocarditis
I40.9Acute myocarditis, unspecified
I51.4Myocarditis, unspecified
I73.0Raynaud's syndrome
I73.00Raynaud's syndrome without gangrene
I73.01Raynaud's syndrome with gangrene
I73.1Thromboangiitis obliterans [Buerger's disease]
I73.8Other specified peripheral vascular diseases
I73.81Erythromelalgia
I73.89Other specified peripheral vascular diseases
I73.9Peripheral vascular disease, unspecified
J10.82Influenza due to other identified influenza virus with myocarditis
J11.82Influenza due to unidentified influenza virus with myocarditis
J39.0Retropharyngeal and parapharyngeal abscess
J39.1Other abscess of pharynx
J39.2Other diseases of pharynx
J39.3Upper respiratory tract hypersensitivity reaction, site unspecified
J39.8Other specified diseases of upper respiratory tract
J39.9Disease of upper respiratory tract, unspecified
L63.0Alopecia (capitis) totalis
L63.1Alopecia universalis
L63.2Ophiasis
L63.8Other alopecia areata
L63.9Alopecia areata, unspecified
L64.0Drug-induced androgenic alopecia
L64.8Other androgenic alopecia
L64.9Androgenic alopecia, unspecified
L65.0Telogen effluvium
L65.1Anagen effluvium
L65.2Alopecia mucinosa
L65.8Other specified nonscarring hair loss
L65.9Nonscarring hair loss, unspecified
L93.0Discoid lupus erythematosus
L93.1Subacute cutaneous lupus erythematosus
L93.2Other local lupus erythematosus
M32.0Drug-induced systemic lupus erythematosus
M32.1Systemic lupus erythematosus with organ or system involvement
M32.10Systemic lupus erythematosus, organ or system involvement unspecified
M32.11Endocarditis in systemic lupus erythematosus
M32.12Pericarditis in systemic lupus erythematosus
M32.13Lung involvement in systemic lupus erythematosus
M32.14Glomerular disease in systemic lupus erythematosus
M32.15Tubulo-interstitial nephropathy in systemic lupus erythematosus
M32.19Other organ or system involvement in systemic lupus erythematosus
M32.8Other forms of systemic lupus erythematosus
M32.9Systemic lupus erythematosus, unspecified
N70.0Acute salpingitis and oophoritis
N70.01Acute salpingitis
N70.02Acute oophoritis
N70.03Acute salpingitis and oophoritis
N70.1Chronic salpingitis and oophoritis
N70.11Chronic salpingitis
N70.12Chronic oophoritis
N70.13Chronic salpingitis and oophoritis
N70.9Salpingitis and oophoritis, unspecified
N70.91Salpingitis, unspecified
N70.92Oophoritis, unspecified
N70.93Salpingitis and oophoritis, unspecified
N73.0Acute parametritis and pelvic cellulitis
N73.1Chronic parametritis and pelvic cellulitis
N73.2Unspecified parametritis and pelvic cellulitis
N73.3Female acute pelvic peritonitis
N73.4Female chronic pelvic peritonitis
N73.5Female pelvic peritonitis, unspecified
N73.6Female pelvic peritoneal adhesions (postinfective)
N73.8Other specified female pelvic inflammatory diseases
N73.9Female pelvic inflammatory disease, unspecified
N88.0Leukoplakia of cervix uteri
N88.1Old laceration of cervix uteri
N88.2Stricture and stenosis of cervix uteri
N88.3Incompetence of cervix uteri
N88.4Hypertrophic elongation of cervix uteri
N88.8Other specified noninflammatory disorders of cervix uteri
N88.9Noninflammatory disorder of cervix uteri, unspecified
N89.0Mild vaginal dysplasia
N89.1Moderate vaginal dysplasia
N89.3Dysplasia of vagina, unspecified
N89.4Leukoplakia of vagina
N89.5Stricture and atresia of vagina
N89.6Tight hymenal ring
N89.7Hematocolpos
N89.8Other specified noninflammatory disorders of vagina
N89.9Noninflammatory disorder of vagina, unspecified
N90.0Mild vulvar dysplasia
N90.1Moderate vulvar dysplasia
N90.3Dysplasia of vulva, unspecified
N90.4Leukoplakia of vulva
N90.5Atrophy of vulva
N90.6Hypertrophy of vulva
N90.60Unspecified hypertrophy of vulva
N90.61Childhood asymmetric labium majus enlargement
N90.69Other specified hypertrophy of vulva
N90.7Vulvar cyst
N90.8Other specified noninflammatory disorders of vulva and perineum
N90.81Female genital mutilation status
N90.810Female genital mutilation status, unspecified
N90.811Female genital mutilation Type I status
N90.812Female genital mutilation Type II status
N90.813Female genital mutilation Type III status
N90.818Other female genital mutilation status
N90.89Other specified noninflammatory disorders of vulva and perineum
N90.9Noninflammatory disorder of vulva and perineum, unspecified
O09.0Supervision of pregnancy with history of infertility
O09.00Supervision of pregnancy with history of infertility, unspecified trimester
O09.01Supervision of pregnancy with history of infertility, first trimester
O09.02Supervision of pregnancy with history of infertility, second trimester
O09.03Supervision of pregnancy with history of infertility, third trimester
O09.1Supervision of pregnancy with history of ectopic pregnancy
O09.10Supervision of pregnancy with history of ectopic pregnancy, unspecified trimester
O09.11Supervision of pregnancy with history of ectopic pregnancy, first trimester
O09.12Supervision of pregnancy with history of ectopic pregnancy, second trimester
O09.13Supervision of pregnancy with history of ectopic pregnancy, third trimester
O09.2Supervision of pregnancy with other poor reproductive or obstetric history
O09.21Supervision of pregnancy with history of pre-term labor
O09.211Supervision of pregnancy with history of pre-term labor, first trimester
O09.212Supervision of pregnancy with history of pre-term labor, second trimester
O09.213Supervision of pregnancy with history of pre-term labor, third trimester
O09.219Supervision of pregnancy with history of pre-term labor, unspecified trimester
O09.29Supervision of pregnancy with other poor reproductive or obstetric history
O09.291Supervision of pregnancy with other poor reproductive or obstetric history, first trimester
O09.292Supervision of pregnancy with other poor reproductive or obstetric history, second trimester
O09.293Supervision of pregnancy with other poor reproductive or obstetric history, third trimester
O09.299Supervision of pregnancy with other poor reproductive or obstetric history, unspecified trimester
O09.3Supervision of pregnancy with insufficient antenatal care
O09.30Supervision of pregnancy with insufficient antenatal care, unspecified trimester
O09.31Supervision of pregnancy with insufficient antenatal care, first trimester
O09.32Supervision of pregnancy with insufficient antenatal care, second trimester
O09.33Supervision of pregnancy with insufficient antenatal care, third trimester
O09.4Supervision of pregnancy with grand multiparity
O09.40Supervision of pregnancy with grand multiparity, unspecified trimester
O09.41Supervision of pregnancy with grand multiparity, first trimester
O09.42Supervision of pregnancy with grand multiparity, second trimester
O09.43Supervision of pregnancy with grand multiparity, third trimester
O09.5Supervision of elderly primigravida and multigravida
O09.51Supervision of elderly primigravida
O09.511Supervision of elderly primigravida, first trimester
O09.512Supervision of elderly primigravida, second trimester
O09.513Supervision of elderly primigravida, third trimester
O09.519Supervision of elderly primigravida, unspecified trimester
O09.52Supervision of elderly multigravida
O09.521Supervision of elderly multigravida, first trimester
O09.522Supervision of elderly multigravida, second trimester
O09.523Supervision of elderly multigravida, third trimester
O09.529Supervision of elderly multigravida, unspecified trimester
O09.6Supervision of young primigravida and multigravida
O09.61Supervision of young primigravida
O09.611Supervision of young primigravida, first trimester
O09.612Supervision of young primigravida, second trimester
O09.613Supervision of young primigravida, third trimester
O09.619Supervision of young primigravida, unspecified trimester
O09.62Supervision of young multigravida
O09.621Supervision of young multigravida, first trimester
O09.622Supervision of young multigravida, second trimester
O09.623Supervision of young multigravida, third trimester
O09.629Supervision of young multigravida, unspecified trimester
O09.7Supervision of high risk pregnancy due to social problems
O09.70Supervision of high risk pregnancy due to social problems, unspecified trimester
O09.71Supervision of high risk pregnancy due to social problems, first trimester
O09.72Supervision of high risk pregnancy due to social problems, second trimester
O09.73Supervision of high risk pregnancy due to social problems, third trimester
O09.8Supervision of other high risk pregnancies
O09.81Supervision of pregnancy resulting from assisted reproductive technology
O09.811Supervision of pregnancy resulting from assisted reproductive technology, first trimester
O09.812Supervision of pregnancy resulting from assisted reproductive technology, second trimester
O09.813Supervision of pregnancy resulting from assisted reproductive technology, third trimester
O09.819Supervision of pregnancy resulting from assisted reproductive technology, unspecified trimester
O09.82Supervision of pregnancy with history of in utero procedure during previous pregnancy
O09.821Supervision of pregnancy with history of in utero procedure during previous pregnancy, first trimester
O09.822Supervision of pregnancy with history of in utero procedure during previous pregnancy, second trimester
O09.823Supervision of pregnancy with history of in utero procedure during previous pregnancy, third trimester
O09.829Supervision of pregnancy with history of in utero procedure during previous pregnancy, unspecified trimester
O09.89Supervision of other high risk pregnancies
O09.891Supervision of other high risk pregnancies, first trimester
O09.892Supervision of other high risk pregnancies, second trimester
O09.893Supervision of other high risk pregnancies, third trimester
O09.899Supervision of other high risk pregnancies, unspecified trimester
O09.9Supervision of high risk pregnancy, unspecified
O09.90Supervision of high risk pregnancy, unspecified, unspecified trimester
O09.91Supervision of high risk pregnancy, unspecified, first trimester
O09.92Supervision of high risk pregnancy, unspecified, second trimester
O09.93Supervision of high risk pregnancy, unspecified, third trimester
O09.ASupervision of pregnancy with history of molar pregnancy
O09.A0Supervision of pregnancy with history of molar pregnancy, unspecified trimester
O09.A1Supervision of pregnancy with history of molar pregnancy, first trimester
O09.A2Supervision of pregnancy with history of molar pregnancy, second trimester
O09.A3Supervision of pregnancy with history of molar pregnancy, third trimester
O26.0Excessive weight gain in pregnancy
O26.00Excessive weight gain in pregnancy, unspecified trimester
O26.01Excessive weight gain in pregnancy, first trimester
O26.02Excessive weight gain in pregnancy, second trimester
O26.03Excessive weight gain in pregnancy, third trimester
O26.1Low weight gain in pregnancy
O26.10Low weight gain in pregnancy, unspecified trimester
O26.11Low weight gain in pregnancy, first trimester
O26.12Low weight gain in pregnancy, second trimester
O26.13Low weight gain in pregnancy, third trimester
O26.2Pregnancy care for patient with recurrent pregnancy loss
O26.20Pregnancy care for patient with recurrent pregnancy loss, unspecified trimester
O26.21Pregnancy care for patient with recurrent pregnancy loss, first trimester
O26.22Pregnancy care for patient with recurrent pregnancy loss, second trimester
O26.23Pregnancy care for patient with recurrent pregnancy loss, third trimester
O26.3Retained intrauterine contraceptive device in pregnancy
O26.30Retained intrauterine contraceptive device in pregnancy, unspecified trimester
O26.31Retained intrauterine contraceptive device in pregnancy, first trimester
O26.32Retained intrauterine contraceptive device in pregnancy, second trimester
O26.33Retained intrauterine contraceptive device in pregnancy, third trimester
O26.4Herpes gestationis
O26.40Herpes gestationis, unspecified trimester
O26.41Herpes gestationis, first trimester
O26.42Herpes gestationis, second trimester
O26.43Herpes gestationis, third trimester
O26.5Maternal hypotension syndrome
O26.50Maternal hypotension syndrome, unspecified trimester
O26.51Maternal hypotension syndrome, first trimester
O26.52Maternal hypotension syndrome, second trimester
O26.53Maternal hypotension syndrome, third trimester
O26.6Liver and biliary tract disorders in pregnancy, childbirth and the puerperium
O26.61Liver and biliary tract disorders in pregnancy
O26.611Liver and biliary tract disorders in pregnancy, first trimester
O26.612Liver and biliary tract disorders in pregnancy, second trimester
O26.613Liver and biliary tract disorders in pregnancy, third trimester
O26.619Liver and biliary tract disorders in pregnancy, unspecified trimester
O26.62Liver and biliary tract disorders in childbirth
O26.63Liver and biliary tract disorders in the puerperium
O26.7Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium
O26.71Subluxation of symphysis (pubis) in pregnancy
O26.711Subluxation of symphysis (pubis) in pregnancy, first trimester
O26.712Subluxation of symphysis (pubis) in pregnancy, second trimester
O26.713Subluxation of symphysis (pubis) in pregnancy, third trimester
O26.719Subluxation of symphysis (pubis) in pregnancy, unspecified trimester
O26.72Subluxation of symphysis (pubis) in childbirth
O26.73Subluxation of symphysis (pubis) in the puerperium
O26.8Other specified pregnancy related conditions
O26.81Pregnancy related exhaustion and fatigue
O26.811Pregnancy related exhaustion and fatigue, first trimester
O26.812Pregnancy related exhaustion and fatigue, second trimester
O26.813Pregnancy related exhaustion and fatigue, third trimester
O26.819Pregnancy related exhaustion and fatigue, unspecified trimester
O26.82Pregnancy related peripheral neuritis
O26.821Pregnancy related peripheral neuritis, first trimester
O26.822Pregnancy related peripheral neuritis, second trimester
O26.823Pregnancy related peripheral neuritis, third trimester
O26.829Pregnancy related peripheral neuritis, unspecified trimester
O26.83Pregnancy related renal disease
O26.831Pregnancy related renal disease, first trimester
O26.832Pregnancy related renal disease, second trimester
O26.833Pregnancy related renal disease, third trimester
O26.839Pregnancy related renal disease, unspecified trimester
O26.84Uterine size-date discrepancy complicating pregnancy
O26.841Uterine size-date discrepancy, first trimester
O26.842Uterine size-date discrepancy, second trimester
O26.843Uterine size-date discrepancy, third trimester
O26.849Uterine size-date discrepancy, unspecified trimester
O26.85Spotting complicating pregnancy
O26.851Spotting complicating pregnancy, first trimester
O26.852Spotting complicating pregnancy, second trimester
O26.853Spotting complicating pregnancy, third trimester
O26.859Spotting complicating pregnancy, unspecified trimester
O26.86Pruritic urticarial papules and plaques of pregnancy (PUPPP)
O26.87Cervical shortening
O26.872Cervical shortening, second trimester
O26.873Cervical shortening, third trimester
O26.879Cervical shortening, unspecified trimester
O26.89Other specified pregnancy related conditions
O26.891Other specified pregnancy related conditions, first trimester
O26.892Other specified pregnancy related conditions, second trimester
O26.893Other specified pregnancy related conditions, third trimester
O26.899Other specified pregnancy related conditions, unspecified trimester
O26.9Pregnancy related conditions, unspecified
O26.90Pregnancy related conditions, unspecified, unspecified trimester
O26.91Pregnancy related conditions, unspecified, first trimester
O26.92Pregnancy related conditions, unspecified, second trimester
O26.93Pregnancy related conditions, unspecified, third trimester
O98.0Tuberculosis complicating pregnancy, childbirth and the puerperium
O98.01Tuberculosis complicating pregnancy
O98.011Tuberculosis complicating pregnancy, first trimester
O98.012Tuberculosis complicating pregnancy, second trimester
O98.013Tuberculosis complicating pregnancy, third trimester
O98.019Tuberculosis complicating pregnancy, unspecified trimester
O98.02Tuberculosis complicating childbirth
O98.03Tuberculosis complicating the puerperium
O98.1Syphilis complicating pregnancy, childbirth and the puerperium
O98.11Syphilis complicating pregnancy
O98.111Syphilis complicating pregnancy, first trimester
O98.112Syphilis complicating pregnancy, second trimester
O98.113Syphilis complicating pregnancy, third trimester
O98.119Syphilis complicating pregnancy, unspecified trimester
O98.12Syphilis complicating childbirth
O98.13Syphilis complicating the puerperium
O98.2Gonorrhea complicating pregnancy, childbirth and the puerperium
O98.21Gonorrhea complicating pregnancy
O98.211Gonorrhea complicating pregnancy, first trimester
O98.212Gonorrhea complicating pregnancy, second trimester
O98.213Gonorrhea complicating pregnancy, third trimester
O98.219Gonorrhea complicating pregnancy, unspecified trimester
O98.22Gonorrhea complicating childbirth
O98.23Gonorrhea complicating the puerperium
O98.3Other infections with a predominantly sexual mode of transmission complicating pregnancy, childbirth and the puerperium
O98.31Other infections with a predominantly sexual mode of transmission complicating pregnancy
O98.311Other infections with a predominantly sexual mode of transmission complicating pregnancy, first trimester
O98.312Other infections with a predominantly sexual mode of transmission complicating pregnancy, second trimester
O98.313Other infections with a predominantly sexual mode of transmission complicating pregnancy, third trimester
O98.319Other infections with a predominantly sexual mode of transmission complicating pregnancy, unspecified trimester
O98.32Other infections with a predominantly sexual mode of transmission complicating childbirth
O98.33Other infections with a predominantly sexual mode of transmission complicating the puerperium
O98.4Viral hepatitis complicating pregnancy, childbirth and the puerperium
O98.41Viral hepatitis complicating pregnancy
O98.411Viral hepatitis complicating pregnancy, first trimester
O98.412Viral hepatitis complicating pregnancy, second trimester
O98.413Viral hepatitis complicating pregnancy, third trimester
O98.419Viral hepatitis complicating pregnancy, unspecified trimester
O98.42Viral hepatitis complicating childbirth
O98.43Viral hepatitis complicating the puerperium
O98.5Other viral diseases complicating pregnancy, childbirth and the puerperium
O98.51Other viral diseases complicating pregnancy
O98.511Other viral diseases complicating pregnancy, first trimester
O98.512Other viral diseases complicating pregnancy, second trimester
O98.513Other viral diseases complicating pregnancy, third trimester
O98.519Other viral diseases complicating pregnancy, unspecified trimester
O98.52Other viral diseases complicating childbirth
O98.53Other viral diseases complicating the puerperium
O98.6Protozoal diseases complicating pregnancy, childbirth and the puerperium
O98.61Protozoal diseases complicating pregnancy
O98.611Protozoal diseases complicating pregnancy, first trimester
O98.612Protozoal diseases complicating pregnancy, second trimester
O98.613Protozoal diseases complicating pregnancy, third trimester
O98.619Protozoal diseases complicating pregnancy, unspecified trimester
O98.62Protozoal diseases complicating childbirth
O98.63Protozoal diseases complicating the puerperium
O98.7Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium
O98.71Human immunodeficiency virus [HIV] disease complicating pregnancy
O98.711Human immunodeficiency virus [HIV] disease complicating pregnancy, first trimester
O98.712Human immunodeficiency virus [HIV] disease complicating pregnancy, second trimester
O98.713Human immunodeficiency virus [HIV] disease complicating pregnancy, third trimester
O98.719Human immunodeficiency virus [HIV] disease complicating pregnancy, unspecified trimester
O98.72Human immunodeficiency virus [HIV] disease complicating childbirth
O98.73Human immunodeficiency virus [HIV] disease complicating the puerperium
O98.8Other maternal infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium
O98.81Other maternal infectious and parasitic diseases complicating pregnancy
O98.811Other maternal infectious and parasitic diseases complicating pregnancy, first trimester
O98.812Other maternal infectious and parasitic diseases complicating pregnancy, second trimester
O98.813Other maternal infectious and parasitic diseases complicating pregnancy, third trimester
O98.819Other maternal infectious and parasitic diseases complicating pregnancy, unspecified trimester
O98.82Other maternal infectious and parasitic diseases complicating childbirth
O98.83Other maternal infectious and parasitic diseases complicating the puerperium
O98.9Unspecified maternal infectious and parasitic disease complicating pregnancy, childbirth and the puerperium
O98.91Unspecified maternal infectious and parasitic disease complicating pregnancy
O98.911Unspecified maternal infectious and parasitic disease complicating pregnancy, first trimester
O98.912Unspecified maternal infectious and parasitic disease complicating pregnancy, second trimester
O98.913Unspecified maternal infectious and parasitic disease complicating pregnancy, third trimester
O98.919Unspecified maternal infectious and parasitic disease complicating pregnancy, unspecified trimester
O98.92Unspecified maternal infectious and parasitic disease complicating childbirth
O98.93Unspecified maternal infectious and parasitic disease complicating the puerperium
R41.0Disorientation, unspecified
R41.1Anterograde amnesia
R41.2Retrograde amnesia
R41.3Other amnesia
R41.4Neurologic neglect syndrome
R41.8Other symptoms and signs involving cognitive functions and awareness
R41.81Age-related cognitive decline
R41.82Altered mental status, unspecified
R41.83Borderline intellectual functioning
R41.84Other specified cognitive deficit
R41.840Attention and concentration deficit
R41.841Cognitive communication deficit
R41.842Visuospatial deficit
R41.843Psychomotor deficit
R41.844Frontal lobe and executive function deficit
R41.89Other symptoms and signs involving cognitive functions and awareness
R41.9Unspecified symptoms and signs involving cognitive functions and awareness
T86.0Complications of bone marrow transplant
T86.00Unspecified complication of bone marrow transplant
T86.01Bone marrow transplant rejection
T86.02Bone marrow transplant failure
T86.03Bone marrow transplant infection
T86.09Other complications of bone marrow transplant
T86.1Complications of kidney transplant
T86.10Unspecified complication of kidney transplant
T86.11Kidney transplant rejection
T86.12Kidney transplant failure
T86.13Kidney transplant infection
T86.19Other complication of kidney transplant
T86.2Complications of heart transplant
T86.20Unspecified complication of heart transplant
T86.21Heart transplant rejection
T86.22Heart transplant failure
T86.23Heart transplant infection
T86.29Other complications of heart transplant
T86.290Cardiac allograft vasculopathy
T86.298Other complications of heart transplant
T86.3Complications of heart-lung transplant
T86.30Unspecified complication of heart-lung transplant
T86.31Heart-lung transplant rejection
T86.32Heart-lung transplant failure
T86.33Heart-lung transplant infection
T86.39Other complications of heart-lung transplant
T86.4Complications of liver transplant
T86.40Unspecified complication of liver transplant
T86.41Liver transplant rejection
T86.42Liver transplant failure
T86.43Liver transplant infection
T86.49Other complications of liver transplant
T86.5Complications of stem cell transplant
T86.8Complications of other transplanted organs and tissues
T86.81Complications of lung transplant
T86.810Lung transplant rejection
T86.811Lung transplant failure
T86.812Lung transplant infection
T86.818Other complications of lung transplant
T86.819Unspecified complication of lung transplant
T86.82Complications of skin graft (allograft) (autograft)
T86.820Skin graft (allograft) rejection
T86.821Skin graft (allograft) (autograft) failure
T86.822Skin graft (allograft) (autograft) infection
T86.828Other complications of skin graft (allograft) (autograft)
T86.829Unspecified complication of skin graft (allograft) (autograft)
T86.83Complications of bone graft
T86.830Bone graft rejection
T86.831Bone graft failure
T86.832Bone graft infection
T86.838Other complications of bone graft
T86.839Unspecified complication of bone graft
T86.84Complications of corneal transplant
T86.840Corneal transplant rejection
T86.8401Corneal transplant rejection, right eye
T86.8402Corneal transplant rejection, left eye
T86.8403Corneal transplant rejection, bilateral
T86.8409Corneal transplant rejection, unspecified eye
T86.841Corneal transplant failure
T86.8411Corneal transplant failure, right eye
T86.8412Corneal transplant failure, left eye
T86.8413Corneal transplant failure, bilateral
T86.8419Corneal transplant failure, unspecified eye
T86.842Corneal transplant infection
T86.8421Corneal transplant infection, right eye
T86.8422Corneal transplant infection, left eye
T86.8423Corneal transplant infection, bilateral
T86.8429Corneal transplant infection, unspecified eye
T86.848Other complications of corneal transplant
T86.8481Other complications of corneal transplant, right eye
T86.8482Other complications of corneal transplant, left eye
T86.8483Other complications of corneal transplant, bilateral
T86.8489Other complications of corneal transplant, unspecified eye
T86.849Unspecified complication of corneal transplant
T86.8491Unspecified complication of corneal transplant, right eye
T86.8492Unspecified complication of corneal transplant, left eye
T86.8493Unspecified complication of corneal transplant, bilateral
T86.8499Unspecified complication of corneal transplant, unspecified eye
T86.85Complication of intestine transplant
T86.850Intestine transplant rejection
T86.851Intestine transplant failure
T86.852Intestine transplant infection
T86.858Other complications of intestine transplant
T86.859Unspecified complication of intestine transplant
T86.89Complications of other transplanted tissue
T86.890Other transplanted tissue rejection
T86.891Other transplanted tissue failure
T86.892Other transplanted tissue infection
T86.898Other complications of other transplanted tissue
T86.899Unspecified complication of other transplanted tissue
T86.9Complication of unspecified transplanted organ and tissue
T86.90Unspecified complication of unspecified transplanted organ and tissue
T86.91Unspecified transplanted organ and tissue rejection
T86.92Unspecified transplanted organ and tissue failure
T86.93Unspecified transplanted organ and tissue infection
T86.99Other complications of unspecified transplanted organ and tissue
Z34.0Encounter for supervision of normal first pregnancy
Z34.00Encounter for supervision of normal first pregnancy, unspecified trimester
Z34.01Encounter for supervision of normal first pregnancy, first trimester
Z34.02Encounter for supervision of normal first pregnancy, second trimester
Z34.03Encounter for supervision of normal first pregnancy, third trimester
Z34.8Encounter for supervision of other normal pregnancy
Z34.80Encounter for supervision of other normal pregnancy, unspecified trimester
Z34.81Encounter for supervision of other normal pregnancy, first trimester
Z34.82Encounter for supervision of other normal pregnancy, second trimester
Z34.83Encounter for supervision of other normal pregnancy, third trimester
Z34.9Encounter for supervision of normal pregnancy, unspecified
Z34.90Encounter for supervision of normal pregnancy, unspecified, unspecified trimester
Z34.91Encounter for supervision of normal pregnancy, unspecified, first trimester
Z34.92Encounter for supervision of normal pregnancy, unspecified, second trimester
Z34.93Encounter for supervision of normal pregnancy, unspecified, third trimester

References
  • Sex Transm Dis. 1998;25:569. [PMID:9858355]
  • Int J STD AIDS. 1995 Jul-Aug;6(4):241-8. [PMID:7548285]
  • J Emerg Med. 2000;18:361. [PMID:10729677]
  • Dermatol Clin .2006;24:497. [PMID:17010778]
  • Stevens CD. Clinical Immunology & Serology: A Laboratory Perspective 3rd edition. Philadelphia: F.A. Davis Company (2010).