Breast tumor
Disease

Medical Tests (24)
Screening/Initial Testing (1)
BRCA1 and BRCA2 Gene Mutations Analysis (duplication/deletion and large gene rearrangements)
8
Note:

BRCA1 or BRCA2 is a screening test for hereditary breast ovarian cancer syndrome (HBOC syndrome). It is used for screening in patient with family history of HBOC or multiple non-hereditary risk factors for breast cancer. First-tier test to assess risk for BRCA-related breast and/or ovarian cancer syndrome in Ashkenazi Jewish people with or without a family history of an ethnicity-associated mutation.

Diagnostic Testing (8)
Biopsy, Breast (Core Needle Biopsy/Fine Needle Aspiration)
10
Note:

Fine needle aspiration or breast biopsy excisional can be done as an alternative,

HER2/neu (ERBB2) Gene Amplification, FISH, Breast Cancer
9
Note:

Used if breast cancer is diagnosed and for therapy selection.

HER2/neu (ERBB2), IHC, Semi Quantitative, Automated
9
Note:

Used if breast cancer is diagnosed and for therapy selection.

Estrogen/Progesterone Receptor, IHC, Semi-Quantitative
8
Note:

Used if breast cancer is diagnosed, for therapy selection.

Hepatic Function Panel (Liver Panel)
6
Note:

Monitor liver enzymes related to cancer spread. Some components of this panel might be part of comprehensive metabolic panel.

Disease Management Testing (8)
Breast Cancer Antigen CA 15-3
10
Note:

If cancer is diagnosed.

Cancer Antigen (CA) 27- 29
8
Note:

If cancer is diagnosed.

Basic Metabolic Panel (BMP)
6
Note:

Alternative to Comprehensive Metabolic Panel.

Biopsy, Sentinel Lymph Node
6
Note:

If disease management tests are elevated and if cancer spread to lymph notes is anticipated.

Bone Alkaline Phosphatase, Serum
6
Note:

If indication for cancer spread to bone exists.

Circulating Tumor Cells (CTC), Breast Cancer (Cellsearch®)
6
Note:

If cancer diagnosed to evaluate for metastatic disease.

NTRK Gene Fusion Panel (NTRK1, NTRK2, and NTRK3), Solid Tumors
6
Note:

In solid tumors, the presence of an NTRK gene fusion is a biomarker for response to tropomyosin receptor kinase (TRK) inhibitor therapies.

Other Supportive/Alternative Tests (7)
Comprehensive Hereditary Cancer Panel, NGS
6
Note:

Supportive in hereditary breast cancer diagnosis.

Hereditary Breast Cancer Gene Mutation Panel, NGS (BreastNext®)
6
Note:

Supportive in hereditary breast cancer diagnosis.

Neurotrophic Receptor Tyrosine Kinase 1 (NTRK1) Gene Mutation Analysis (Translocation)
5
Note:

In solid tumors, the presence of an NTRK gene fusion is a biomarker for response to tropomyosin receptor kinase (TRK) inhibitor therapies.

Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2) Gene Mutation Analysis (Translocation)
5
Note:

In solid tumors, the presence of an NTRK gene fusion is a biomarker for response to tropomyosin receptor kinase (TRK) inhibitor therapies.

Neurotrophic Receptor Tyrosine Kinase 3 (NTRK3) Gene Mutation Analysis (Translocation)
5
Note:

In solid tumors, the presence of an NTRK gene fusion is a biomarker for response to tropomyosin receptor kinase (TRK) inhibitor therapies.

ICD10
C50Malignant neoplasm of breast
D24Benign neoplasm of breast
D24.1Benign neoplasm of right breast
D24.2Benign neoplasm of left breast
D24.9Benign neoplasm of unspecified breast
N63Unspecified lump in breast
N64Other disorders of breast
R92Abnormal and inconclusive findings on diagnostic imaging of breast

Additional ICD10
C44.501Unspecified malignant neoplasm of skin of breast
C44.511Basal cell carcinoma of skin of breast
C44.521Squamous cell carcinoma of skin of breast
C44.591Other specified malignant neoplasm of skin of breast
C50.0Malignant neoplasm of nipple and areola
C50.01Malignant neoplasm of nipple and areola, female
C50.011Malignant neoplasm of nipple and areola, right female breast
C50.012Malignant neoplasm of nipple and areola, left female breast
C50.019Malignant neoplasm of nipple and areola, unspecified female breast
C50.02Malignant neoplasm of nipple and areola, male
C50.021Malignant neoplasm of nipple and areola, right male breast
C50.022Malignant neoplasm of nipple and areola, left male breast
C50.029Malignant neoplasm of nipple and areola, unspecified male breast
C50.1Malignant neoplasm of central portion of breast
C50.11Malignant neoplasm of central portion of breast, female
C50.111Malignant neoplasm of central portion of right female breast
C50.112Malignant neoplasm of central portion of left female breast
C50.119Malignant neoplasm of central portion of unspecified female breast
C50.12Malignant neoplasm of central portion of breast, male
C50.121Malignant neoplasm of central portion of right male breast
C50.122Malignant neoplasm of central portion of left male breast
C50.129Malignant neoplasm of central portion of unspecified male breast
C50.2Malignant neoplasm of upper-inner quadrant of breast
C50.21Malignant neoplasm of upper-inner quadrant of breast, female
C50.211Malignant neoplasm of upper-inner quadrant of right female breast
C50.212Malignant neoplasm of upper-inner quadrant of left female breast
C50.219Malignant neoplasm of upper-inner quadrant of unspecified female breast
C50.22Malignant neoplasm of upper-inner quadrant of breast, male
C50.221Malignant neoplasm of upper-inner quadrant of right male breast
C50.222Malignant neoplasm of upper-inner quadrant of left male breast
C50.229Malignant neoplasm of upper-inner quadrant of unspecified male breast
C50.3Malignant neoplasm of lower-inner quadrant of breast
C50.31Malignant neoplasm of lower-inner quadrant of breast, female
C50.311Malignant neoplasm of lower-inner quadrant of right female breast
C50.312Malignant neoplasm of lower-inner quadrant of left female breast
C50.319Malignant neoplasm of lower-inner quadrant of unspecified female breast
C50.32Malignant neoplasm of lower-inner quadrant of breast, male
C50.321Malignant neoplasm of lower-inner quadrant of right male breast
C50.322Malignant neoplasm of lower-inner quadrant of left male breast
C50.329Malignant neoplasm of lower-inner quadrant of unspecified male breast
C50.4Malignant neoplasm of upper-outer quadrant of breast
C50.41Malignant neoplasm of upper-outer quadrant of breast, female
C50.411Malignant neoplasm of upper-outer quadrant of right female breast
C50.412Malignant neoplasm of upper-outer quadrant of left female breast
C50.419Malignant neoplasm of upper-outer quadrant of unspecified female breast
C50.42Malignant neoplasm of upper-outer quadrant of breast, male
C50.421Malignant neoplasm of upper-outer quadrant of right male breast
C50.422Malignant neoplasm of upper-outer quadrant of left male breast
C50.429Malignant neoplasm of upper-outer quadrant of unspecified male breast
C50.5Malignant neoplasm of lower-outer quadrant of breast
C50.51Malignant neoplasm of lower-outer quadrant of breast, female
C50.511Malignant neoplasm of lower-outer quadrant of right female breast
C50.512Malignant neoplasm of lower-outer quadrant of left female breast
C50.519Malignant neoplasm of lower-outer quadrant of unspecified female breast
C50.52Malignant neoplasm of lower-outer quadrant of breast, male
C50.521Malignant neoplasm of lower-outer quadrant of right male breast
C50.522Malignant neoplasm of lower-outer quadrant of left male breast
C50.529Malignant neoplasm of lower-outer quadrant of unspecified male breast
C50.6Malignant neoplasm of axillary tail of breast
C50.61Malignant neoplasm of axillary tail of breast, female
C50.611Malignant neoplasm of axillary tail of right female breast
C50.612Malignant neoplasm of axillary tail of left female breast
C50.619Malignant neoplasm of axillary tail of unspecified female breast
C50.62Malignant neoplasm of axillary tail of breast, male
C50.621Malignant neoplasm of axillary tail of right male breast
C50.622Malignant neoplasm of axillary tail of left male breast
C50.629Malignant neoplasm of axillary tail of unspecified male breast
C50.8Malignant neoplasm of overlapping sites of breast
C50.81Malignant neoplasm of overlapping sites of breast, female
C50.811Malignant neoplasm of overlapping sites of right female breast
C50.812Malignant neoplasm of overlapping sites of left female breast
C50.819Malignant neoplasm of overlapping sites of unspecified female breast
C50.82Malignant neoplasm of overlapping sites of breast, male
C50.821Malignant neoplasm of overlapping sites of right male breast
C50.822Malignant neoplasm of overlapping sites of left male breast
C50.829Malignant neoplasm of overlapping sites of unspecified male breast
C50.9Malignant neoplasm of breast of unspecified site
C50.91Malignant neoplasm of breast of unspecified site, female
C50.911Malignant neoplasm of unspecified site of right female breast
C50.912Malignant neoplasm of unspecified site of left female breast
C50.919Malignant neoplasm of unspecified site of unspecified female breast
C50.92Malignant neoplasm of breast of unspecified site, male
C50.921Malignant neoplasm of unspecified site of right male breast
C50.922Malignant neoplasm of unspecified site of left male breast
C50.929Malignant neoplasm of unspecified site of unspecified male breast
D24.1Benign neoplasm of right breast
D24.2Benign neoplasm of left breast
D24.9Benign neoplasm of unspecified breast
N63.0Unspecified lump in unspecified breast
N63.1Unspecified lump in the right breast
N63.10Unspecified lump in the right breast, unspecified quadrant
N63.11Unspecified lump in the right breast, upper outer quadrant
N63.12Unspecified lump in the right breast, upper inner quadrant
N63.13Unspecified lump in the right breast, lower outer quadrant
N63.14Unspecified lump in the right breast, lower inner quadrant
N63.15Unspecified lump in the right breast, overlapping quadrants
N63.2Unspecified lump in the left breast
N63.20Unspecified lump in the left breast, unspecified quadrant
N63.21Unspecified lump in the left breast, upper outer quadrant
N63.22Unspecified lump in the left breast, upper inner quadrant
N63.23Unspecified lump in the left breast, lower outer quadrant
N63.24Unspecified lump in the left breast, lower inner quadrant
N63.25Unspecified lump in the left breast, overlapping quadrants
N63.3Unspecified lump in axillary tail
N63.31Unspecified lump in axillary tail of the right breast
N63.32Unspecified lump in axillary tail of the left breast
N63.4Unspecified lump in breast, subareolar
N63.41Unspecified lump in right breast, subareolar
N63.42Unspecified lump in left breast, subareolar
N64.0Fissure and fistula of nipple
N64.1Fat necrosis of breast
N64.2Atrophy of breast
N64.3Galactorrhea not associated with childbirth
N64.4Mastodynia
N64.5Other signs and symptoms in breast
N64.51Induration of breast
N64.52Nipple discharge
N64.53Retraction of nipple
N64.59Other signs and symptoms in breast
N64.8Other specified disorders of breast
N64.81Ptosis of breast
N64.82Hypoplasia of breast
N64.89Other specified disorders of breast
N64.9Disorder of breast, unspecified
R92.0Mammographic microcalcification found on diagnostic imaging of breast
R92.1Mammographic calcification found on diagnostic imaging of breast
R92.2Inconclusive mammogram
R92.8Other abnormal and inconclusive findings on diagnostic imaging of breast
Z12.3Encounter for screening for malignant neoplasm of breast
Z12.39Encounter for other screening for malignant neoplasm of breast
Z15.01Genetic susceptibility to malignant neoplasm of breast
Z85.3Personal history of malignant neoplasm of breast
Z86.000Personal history of in-situ neoplasm of breast

SNOMED
269485000Benign tumor of breast